4 user
1:08 | Trailer
Crypto is back with the Furons to take over in all parts of the world.


Tom Abernathy (head writer)

Photos We Love From Our Favorite Video Games

Check out this collection of photos we love from some of our favorite video games. See our Video Games Guide for more.

See the full gallery

3 nominations. See more awards »



Add Image Add an image

Do you have any images for this title?

Learn more

More Like This 

Destroy All Humans! (Video Game 2005)
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 7.9/10 X  

You are Cryptospordium-137, a Furon sent to Earth to collect Furon DNA embedded in humans.

Director: Brad Welch
Stars: J. Grant Albrecht, Richard Steven Horvitz, André Sogliuzzo
Action | Comedy | Horror
    1 2 3 4 5 6 7 8 9 10 7.3/10 X  

It's the late 1970's, and Crypto faces a conspiracy so vast that even Pox can't help him now.

Directors: Jon Knoles, Douglas Carrigan
Stars: J. Grant Albrecht, Richard Steven Horvitz, Darryl Kurylo
Comedy | Horror
    1 2 3 4 5 6 7 8 9 10 7/10 X  

Crypto and Pox have started a fast food restaurant and the secret recipe is human meat and they serve human meat to collect brain stems which is code named DNA and they harvest the Furon DNA once again.

Directors: Ken Allen, Douglas Carrigan
Stars: Sean Donnellan, Darryl Kurylo, Courtenay Taylor
The Simpsons: Hit & Run (Video Game 2003)
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 8.2/10 X  

When mysterious surveillance equipment, mind control cola and aliens terrorize Springfield, only the Simpsons can find out why and save the town.

Stars: Dan Castellaneta, Julie Kavner, Nancy Cartwright
The Simpsons: Road Rage (Video Game 2001)
Action | Comedy
    1 2 3 4 5 6 7 8 9 10 7.4/10 X  

Mr. Burns has bought all transit systems in Springfield, the citizens must use their own cars as a means of safer public transport and earn money in an attempt to pay back Burns.

Stars: Dan Castellaneta, Julie Kavner, Nancy Cartwright
Lego Star Wars: The Video Game (Video Game 2005)
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 8.1/10 X  

Play through the Star Wars prequel trilogy in Episodes I, II and III in Lego.

Director: Jon Burton
Stars: Ahmed Best, Hayden Christensen, Anthony Daniels
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 8.3/10 X  

Play the original trilogy of Star Wars: A New Hope, The Empire Strikes Back, and Return of the Jedi, all in Lego.

Stars: Tom Kane, David W. Collins, Peter Cushing
Action | Adventure | Drama
    1 2 3 4 5 6 7 8 9 10 7.3/10 X  

Game that portrays the life of a jedi knight and sith lords, while you find your way around the galaxy, as you become part of the story.

Director: Adam Schnitzer
Stars: Corey Burton, Terrence 'T.C.' Carson, Andrew Chaikin
Wolfenstein 3D (Video Game 1992)
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 8.1/10 X  

In Castle Wolfenstein 3D you play an American P.O.W. trying desperately to escape from the Nazi prison Wolfenstein during World War II.

Director: John Romero
Marvel: Ultimate Alliance 2 (Video Game 2009)
Action | Adventure | Fantasy
    1 2 3 4 5 6 7 8 9 10 7.6/10 X  

Ultimate Alliance 2 features characters from the Marvel universe and follows elements of the Secret War and Civil War story arcs from the comic.

Directors: Ali Donovan, Dan Tanguay
Stars: David Agranov, Lori Alan, Ogie Banks
Brütal Legend (Video Game 2009)
Action | Adventure | Comedy
    1 2 3 4 5 6 7 8 9 10 8.1/10 X  

Eddie Riggs, a roadie, is transported to a fantasy world inspired by the artwork of heavy metal album covers, and becomes the world's savior, leading the down-trodden humans against a range of supernatural overlords.

Director: Tim Schafer
Stars: Jack Black, Jennifer Hale, Zach Hanks
Lollipop Chainsaw (Video Game 2012)
Action | Comedy | Horror
    1 2 3 4 5 6 7 8 9 10 7.6/10 X  

Juliet Starling uncovers the root of a zombie outbreak. She must balance the drama of high school while carrying out her zombie-hunting lineage and chainsaw skills to string together lethal combo moves, taking out scores of the undead.

Director: Suda 51
Stars: Tara Strong, Michael Rosenbaum, Kimberly Brooks


Cast overview, first billed only:
J. Grant Albrecht ... Crypto (voice)
Richard Steven Horvitz ... Orthopox-13 / The Freak (voice)
Anthony Head ... Reginald Ponsonby-Smythe (voice) (as Anthony Stewart Head)
Courtenay Taylor ... Natalya Ivanova / Prudence Kane (voice)
Susanne Blakeslee ... Russian Women / Japanese Women (voice)
Jocelyn Blue Jocelyn Blue ... Japanese Co-Eds (voice)
Steve Blum ... Black Ninjas / Additional Voices (voice) (as Steven Blum)
Edita Brychta ... British Hippies / Additional Voices (voice)
Robin Atkin Downes ... Agent Oranchov / Hippies / Additional Voices (voice)
Keith Ferguson Keith Ferguson ... Bay City Cops / Bay City Soldiers (voice)
Jason Harris ... Astronaut "Biff" / American Men / Additional Voices (voice)
Yuri Lowenthal ... Englishmen / Astronaut 'Carl' / Additional Voices (voice)
Jim Meskimen ... Russian Men / Cosmonauts / Additional Voices (voice)
Phil Morris ... Gastro / Bay City Hippie / Bay City African-American Hippie (voice)
Paul Nakauchi ... Japanese Men / Ninjas / Additional Voices (voice)


Crypto is back with the Furons to take over in all parts of the world.

Plot Summary | Add Synopsis


Make war, not love.


T | See all certifications »

Parents Guide:

View content advisory »


Official Sites:

Official site





Release Date:

17 October 2006 (USA) See more »

Also Known As:

Destroy All Humans! 2 See more »

Company Credits

Show more on IMDbPro »

Did You Know?


In Albion (Parody of London), when Crypto is not in disguise. Citizens scream out, "Where's the bleeding TARDIS?" and "Someone ring the Doctor!" This is referencing Doctor Who as it was majorly popular during the 1960's with both William Hartnell and Patrick Troughton's first and second incarnations of the Doctor. Also when Crypto uses mind control on a citizen to follow they say, "I obey, I obey." referencing the Daleks! See more »


One of the White Ninjas' haiku makes reference to Angelina Jolie, even though, in the game's set year of 1969, she is not born yet. See more »


[first lines]
Ivan Oranchov: Premier comrade Milenkov, comrade agents, thank you for coming. Here's what we know so far.
[a slide show displaying the first game's events and its aftermath is shown]
Ivan Oranchov: Ten years ago, the United States government covered up an invasion by an alien race known as Furons. Their primary agent was this Furon: Cryptosporidium-137, dangerous, unpredictable and now deceased.
Milenkov: So? What is being problem?
Ivan Oranchov: The problem, comrade, is that Furons can clone themselves and pose convincingly as humans,...
See more »


Followed by Destroy All Humans: Path of the Furon (2008) See more »

Frequently Asked Questions

This FAQ is empty. Add the first question.

User Reviews

It honestly was not needed
6 June 2007 | by Infest0125See all my reviews

OK, most of the times sequels are horrible, and this is a perfect example as it is way too annoying with the co-op and the first one was way funnier. It is still a little addicting, but I hated the co-op. Apparently you and you buddy can't be as far as 40 feet away from each other, and you only get 1 saucer with a turret and both people have to be in it to fly it... just horrible. Me and my friend were at each other's throats trying to figure out who flew and who just shot, which almost resulted in a death. We were also arguing over which way to go... and that was really annoying too. Sure it is a little funny, like making prank calls to the police, and it is sweet abducting a tank and smashing hippies with it. But the co-op should allow players to wonder freely and provide 2 UFOs just like halo and stubbs and any other co-op game. 5/10.

3 of 18 people found this review helpful.  Was this review helpful to you? | Report this
Review this title | See all 4 user reviews »

Contribute to This Page

Recently Viewed