An anthrax outbreak is killing Shiloh cattle and threatening the neighboring ranches. The neighbors are wanting to destroy the Shiloh cattle and burn the land to kill the outbreak. Grainger ordered a new vaccine for anthrax that is to arrive the next day. Walker, a bounty hunter, and his female prisoner Ruby show up at Shiloh looking for horses. They are chasing the Johnny Colton gang which held up a stage which turns out to be the one with the vaccine on it. David Sutton and The Virginian go with them to retrieve the vaccine. They find that the gang took the stage and contents with them. They locate the stage but the contents were moved to a spring wagon with the trail headed toward the outlaw town Misadventure. The rules of Misadventure are to mind your own business which The Virginian violates. He makes friends with the saloon singer Claire who tells him where the gang is staying. During the adventure The Virginian and Ruby develop a relationship unappreciated by Walker. In the end...