Star Trek (1966–1969)
20 user 6 critic

Operation - Annihilate! 

The Enterprise crew attempts to stop a plague of amoeba-like creatures from possessing human hosts and spreading throughout the galaxy.


Herschel Daugherty


Steven W. Carabatsos, Gene Roddenberry (created by)

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Episode complete credited cast:
William Shatner ... Capt. Kirk / Sam Kirk
Leonard Nimoy ... Mr. Spock
DeForest Kelley ... Dr. McCoy
James Doohan ... Scott
Joan Swift Joan Swift ... Aurelan Kirk
Maurishka Maurishka ... Yeoman Ellen Zahra
Majel Barrett ... Nurse Christine Chapel
George Takei ... Sulu
Nichelle Nichols ... Uhura
Craig Huxley ... Peter Kirk (as Craig Hundley)
Fred Carson Fred Carson ... First Denevan
Jerry Catron ... Second Denevan


The Enterprise traces a virus-like outbreak that seems to be traveling in a direct line across a planetary system. The next planet is home to Kirk's brother Sam, his sister-in-law and their young son. The Enterprise arrives too late however for Sam. They find flying jellyfish-like creatures that attach themselves to humans. They take over the victims nervous system forcing them to bend to their will. Spock finds a weapon to use against the creatures but it leaves him hopelessly blind. Written by garykmcd

Plot Summary | Plot Synopsis


TV-PG | See all certifications »


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Release Date:

13 April 1967 (USA) See more »

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Did You Know?


The Deneva outdoor scenes were shot at the headquarters of TRW Space and Defense Park in Redondo Beach, California (currently the Northrop Grumman Space Technology headquarters). The establishing shot of Kirk's brother - Sam's lab was a building on the campus of UCLA, and the entrance of the building was the cafeteria at TRW. See Google Earth for location. See more »


In the beginning scenes on the bridge after Uhura raises Kirk's sister-in-law, Uhura is not sitting at the communications station which places Spock's science station to her left; Spock's station can be seen in the background to her right which would place her at the navigation sub-station which is to the left of the science station. When she loses Aurelen's signal and Kirk walks away, she is now sitting at her correct station to the right of the science station. See more »


Dr. McCoy: Unusual eye arrangement. I might've known he'd turn up something like that.
Capt. Kirk: What's that, doctor?
Dr. McCoy: I said, please don't tell Spock I said he was the best first officer in the fleet.
Spock: Why thank you, Dr. McCoy.
Capt. Kirk: You've been so concerned about his Vulcan eyes, Doctor, you forgot about his Vulcan ears.
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Alternate Versions

Special Enhanced version Digitally Remastered with new exterior shots and remade opening theme song See more »


Spoofed in Buffy the Vampire Slayer: Bad Eggs (1998) See more »

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User Reviews

Cold War era commentary
28 May 2009 | by BlueghostSee all my reviews

Like a few other episodes, the story for this particular episode draws it inspiration from the two competing philosophies during the cold war. The audience is posed with Kirk and Spock trying to unravel the mystery of an alien collective intelligence that enslaves infected hosts to do their bidding (think the Soviet Union here).

The theme here is designed to illustrate the slavery that the collective mentality imposes on the human condition. One might find themselves tempted to look up ancient Greek philosophy to explore some of the deeper allegories that are cleverly coded and illustrated in this episode. Note the beginning and the ultimate solution near the end.

Production value wise the creative forces knew they had a turkey when it came to their alien of the week, and so addressed that aspect in some of the dialog from one of the landing party crew members. Otherwise it superbly acted (as are the super-majority of this 1960's gem TV show), and the story, if one is sharp and well educated enough, should strike a chord for anyone who's felt the heel of of an oligarchical power.

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