The nitrous oxide cylinder at the end of the episode is marked N²O. Chemical formulas use subscript for numbers, at least nowadays (the original Berzeluis notation used superscript and was still used during the first half of the 20th century). See more
Now, let's get down to business.
Oh, man. I have to go to the bathroom. Why did I have all that beer and coffee and watermelon?
Now Homer, I know what you're thinking. I want to take the pressure off. Now, it doesn't take a 'whiz' to know that you're looking out for 'Number One'. Well, listen to me, and you'll make a big splash very soon.