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| Episode cast overview, first billed only: | |||
| Peter Gallagher | ... | Sandy Cohen | |
| Kelly Rowan | ... | Kirsten Cohen | |
| Ben McKenzie | ... | Ryan Atwood | |
| Mischa Barton | ... | Marissa Cooper | |
| Adam Brody | ... | Seth Cohen | |
| Melinda Clarke | ... | Julie Cooper | |
| Rachel Bilson | ... | Summer Roberts | |
| Tate Donovan | ... | Jimmy Cooper | |
| Jeri Ryan | ... | Charlotte Morgan | |
| Logan Marshall-Green | ... | Trey Atwood | |
| Garrett M. Brown | ... | Dr. Kenneth Woodruff | |
| Timothy Omundson | ... | Deputy District Attorney Chris Caldwell | |
| Michael Adler | ... | Jeff Frenkel | |
| Stephen O'Mahoney | ... | Cop #1 | |
| Gary Weeks | ... | Cop #2 | |
Ryan and Marissa deal with the aftermath of Trey's shooting when Julie maliciously goes to great efforts to protect her daughter by influencing Trey to charge Ryan for the shooting. Meanwhile, Kirsten meets a shady young woman, named Charlotte, at rehab who inspires her to move on with her life. Sandy also takes over running the Newport Group while Julie and Jimmy wait for news about the late Caleb's accountants. Written by Anonymous