This episode takes place in Mexico in the 15th century.
Margot Van der Burgh (Cameca) returns to the Doctor Who series seventeen years later as Consul Katura in "The Keeper of Traken" (1981) along with Tom Baker's Doctor.
John Ringham (Tlotoxl, the high priest of sacrifice) makes two further appearances as other characters. After "The Aztecs" he appeared as Josiah Blake in "The Smugglers" (1966) (again with William Hartnell's Doctor) and later as Robert Ashe in "Colony in Space" (1971) with Jon Pertwee's Doctor.