| Cast overview, first billed only: | |||
| Karolina Gruszka | ... | Lost Girl | |
| Krzysztof Majchrzak | ... | Phantom | |
| Grace Zabriskie | ... | Visitor #1 | |
| Laura Dern | ... | Nikki Grace / Susan Blue | |
| Jan Hencz | ... | Janek (as Jan Hench) | |
| Ian Abercrombie | ... | Henry the Butler | |
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Karen Baird | ... | Servant |
| Bellina Logan | ... | Linda | |
| Peter J. Lucas | ... | Piotrek Krol | |
| Amanda Foreman | ... | Tracy | |
| Jeremy Irons | ... | Kingsley Stewart | |
| Justin Theroux | ... | Devon Berk / Billy Side | |
| Harry Dean Stanton | ... | Freddie Howard | |
| Cameron Daddo | ... | Devon Berk's Manager | |
| Jerry Stahl | ... | Devon Berk's Agent | |
After an uncomfortable, borderline disturbing visitation by a cryptic neighbour, the fading movie star, Nikki Grace, is thrilled to hear that she has just landed herself the female lead role in director Kingsley Stewart's sensational Southern melodrama called "On High in Blue Tomorrows". However, as she gradually disappears into her complex role, Nikki's character, Susan Blue, starts to emerge from the labyrinthine pathways of her unconscious, creeping into her delicate consciousness. More and more, as Nikki's dissociation becomes more aggressive, and her self-transcendent experience sets in motion a sometimes subtle, sometimes profound transformation, parallel worlds interweave, and a mysterious lost girl tuned into the TV sitcom, Rabbits (2002), begins to take shape. Is Stewart's ambitious project doomed to fail? Written by Nick Riganas
First off, this is easily the most confusing and bizarre of all of David Lynch's films, even more so than Lost Highway. I think it's also the most bizarre film I have ever seen. The film is harrowing and creepy and Laura Dern is incredible in her performance. I never thought she was capable it. Fans of Lynch will love it, especially those who think Mulholland Drive and Lost Highway were his best. Average filmgoers will most likely be bored (it's 3 hours long) or think it is Artsy crap. Lost Highway is probably his most comparable film based on structure, technique, and bizarre elements, although it would not be entirely fair to use Lost Highway as a basis for judgment. One of the only things that keeps me from giving it a higher rating is that there are a couple scenes which seemed to drag on a little longer than necessary. Inland Empire at first is reminiscent of some of Lynch's older short films because of the way it is filmed. It is gritty, shaky, and even gives a documentary feel at first. While it is still not his best, it's among them and it's what Lynch fans have come to expect and love.