When Dean and Sam go missing Jody Mills calls Claire Novak and tells her to come home they need to find the Winchesters. As they search for Kaia the dreamcatcher who opened the rift Jody is worried about Patience's vision.
Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum who manage to steal a powerful book of spells from the Winchesters. When Dean and Sam go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.
Jack and Mary escape Michael's clutches and end up finding an ally in Bobby Singer; Sam, Dean, and Castiel continue to search for a way to open a breach; one of their own may be working against them and costing them precious time.
Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary (guest star Samantha Smith) and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.
Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.
Lucifer rules over heaven but things aren't going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.
Gabriel is back and drags Dean and Sam into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's growing confidence leads to reckless decisions that could put others in harm's way.
Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena's encounter with Lucifer may alter the outcome of the journey for one of our heroes.
Sam enlists everyone's help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.
Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.
Sam and Castiel track down a Shaman who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.
When Dean and Sam join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.
Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.