Claire believes recent murders in town are supernatural and asks Sam and Dean to investigate. However, Sheriff Mills tells the guys that Claire has been getting into trouble lately and has been attacking normal people and accusing them of being monsters.
After dangerous creature is released into an old house, a mother and child are comatose. Sam and Dean find that Bobby and Rufus tracked the same creature so the Winchesters look to the past to catch the monster before any one dies.
Sam and Dean are visiting a small town in Colorado where people are mysteriously disappearing every 27 years. While they are investigating, the boys encounter a pair of hunters seeking revenge on the monster causing the disappearances.
Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.
Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
Lucifer realizes that as Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, he arranges a VIP concert in order to kill them. Sam, Dean and Castiel enter the underbelly of the music industry to stop him.