Sam enlists everyone's help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.
Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.
Sam and Castiel track down a Shaman who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.
When Dean and Sam join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.
Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.