A wraith kills her friend and Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, and could be next on the wraith's hit list. Sam continues to work with Jack to control his powers.
When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.
Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dream walker named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.
When Dean and Sam go missing Jody Mills calls Claire Novak and tells her to come home they need to find the Winchesters. As they search for Kaia the dreamcatcher who opened the rift Jody is worried about Patience's vision.
Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum who manage to steal a powerful book of spells from the Winchesters. When Dean and Sam go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.
Jack and Mary escape Michael's clutches and end up finding an ally in Bobby Singer; Sam, Dean, and Castiel continue to search for a way to open a breach; one of their own may be working against them and costing them precious time.
Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary (guest star Samantha Smith) and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.
Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.
Lucifer rules over heaven but things aren't going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.
Gabriel is back and drags Dean and Sam into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's growing confidence leads to reckless decisions that could put others in harm's way.
Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena's encounter with Lucifer may alter the outcome of the journey for one of our heroes.