Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.
Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
Lucifer realizes that as Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, he arranges a VIP concert in order to kill them. Sam, Dean and Castiel enter the underbelly of the music industry to stop him.
After being arrested for the attempted assassination of the POTUS Sam and Dean must find a way out of a government detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek help from an unlikely source.
Sam and Dean investigate an attack by an invisible hellhound at a campsite. Meanwhile, two of Crowley's own personal demons uncover what he has been hiding. Elsewhere, Castiel gets a lead on Kelly Kline.
Dean and Sam let Mick Davies tag along on a case as they search for a werewolf and they run into Claire Novak, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.
Alicia Banes calls Mary for help after her mother, Tasha goes missing. Sam answers Mary's phone and he and Dean head out to help Alicia and her twin brother, Max find their mother who was hunting a powerful witch. Meanwhile Mary starts to have some doubts about the British Men of Letters.
Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.