An FBI agent takes on a plane full of deadly venomous snakes, deliberately released to kill a witness being flown from Honolulu to Los Angeles to testify against a mob boss.


David R. Ellis


John Heffernan (screenplay), Sebastian Gutierrez (screenplay) | 2 more credits »
2,144 ( 88)
4 wins & 8 nominations. See more awards »





Cast overview, first billed only:
Samuel L. Jackson ... Neville Flynn
Julianna Margulies ... Claire Miller
Nathan Phillips ... Sean Jones
Rachel Blanchard ... Mercedes
Flex Alexander ... Three G's
Kenan Thompson ... Troy
Keith Dallas ... Big Leroy (as Keith [Blackman] Dallas)
Lin Shaye ... Grace
Bruce James ... Ken
Sunny Mabrey ... Tiffany
Casey Dubois Casey Dubois ... Curtis
Daniel Hogarth Daniel Hogarth ... Tommy
Gerard Plunkett ... Paul
Terry Chen ... Chen Leong
Elsa Pataky ... Maria


While practicing motocross in Hawaii, Sean Jones witnesses the brutal murder of an important American prosecutor by the powerful mobster Eddie Kim. FBI agent Neville Flynn persuades him to testify against Eddie in Los Angeles. They board the red-eye Flight 121 of Pacific Air, occupying the entire first-class section. However, Eddie dispatches hundred of different species of snakes airborne with a time-operated device in the luggage to release the snakes into the flight with the intent of crashing the plane. Neville and the passengers must struggle with the snakes to survive. Written by Claudio Carvalho, Rio de Janeiro, Brazil

Plot Summary | Plot Synopsis


On August 18th Summer Really Begins See more »

Motion Picture Rating (MPAA)

Rated R for language, a scene of sexuality and drug use, and intense sequences of terror and violence | See all certifications »

Parents Guide:

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Did You Know?


Julianna Margulies has stated that she's terrified of snakes in real life. In an appearance on the Ellen Degeneres show in 2012, Ellen even tried to scare her with a fake snake. See more »


(at around 1h 27 mins) If the air was rushing by as rapidly as depicted during the depressurization sequence, no one would be able to remain standing against the force. Additionally, with a hole that large in the fuselage, the pressure differential would equalize rapidly, literally in seconds. No amount of differential would be able to pull the snakes off of the floors and out of the cabin as depicted. This much pressure would collapse the floors and walls in the aircraft's interior, and would quite likely create so much structural damage to the aircraft that it would destroy the plane. See more »


[first lines]
Daniel Hayes: [to Sean] Go, get outta here. Go!
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Crazy Credits

Film title appears with plane warning audio as end credits finish See more »

Alternate Versions

The DVD replaces a quick shot of a microwave closeup when the male flight attendant nukes a snake; instead of "popcorn," one button now reads "snake" (it appears to be a physical change and reshoot). This is not indicated anywhere on the DVD, nor is the original available, but the director confirms the change in a comment on See more »


Featured in WatchMojo: Another Top 10 Worst CGI Movie Effects (2015) See more »


Snakes on the Brain
Written by Jonathan Snipes and Brian Miller
Performed by Captain Ahab
See more »

User Reviews

An Event you'll Remember, A Movie You'd Rather Forget
20 August 2006 | by sallyfifthSee all my reviews

The best review of the film portion of this movie is from the Onion AV Club. It sums up Sam Jackson's performance as "done on his lunchbreak while filming a lesser degrading film". And yet, he's the best dang part of the whole thing. What this movie needed was more of him vs. the Snakes which never reaches the insanity of a "Dead Alive" and instead fizzles out in one of the lamer endings in recent cinemadom. You get snakes, on a plane. And some great B- horror moments that'll make you laugh, but this is not a cult classic. Despite people's want for a cult classic here, it's far too normal for that. Instead check out the aforementioned "Dead alive" (aka Brain Dead) or Tsui Hark's hilariously straight "Knock Off" with Van Damm & Rob Schneider. THOSE were bad good flicks this is one is just ho-hum.

On the other hand, the audience is hot for Snakes. As stephanie from says, if you're going to see Snakes, do so now with the packed evening screenings. People throwing rubber snakes, reciting sam's line and making hissing noises throughout makes for theme park ride levels of fun.

30 of 56 people found this review helpful.  Was this review helpful to you? | Report this
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Frequently Asked Questions

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USA | Germany



Release Date:

18 August 2006 (USA) See more »

Also Known As:

Anaconda 3 See more »


Box Office


$33,000,000 (estimated)

Opening Weekend USA:

$13,850,000, 20 August 2006

Gross USA:


Cumulative Worldwide Gross:

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Company Credits

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Technical Specs


Sound Mix:

DTS | Dolby Digital | SDDS



Aspect Ratio:

2.39 : 1
See full technical specs »

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