Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire and the doctors are introduced to a few new faces that spice things up around the hospital.
Amelia confronts a difficult situation; Meredith deals with the fallout from her conversation with Nathan; Maggie finds herself at an awkward family dinner; Jackson receives big news; Richard and Bailey search for the stars of tomorrow.
April is in charge of the new surgical innovation contest; the doctors are eager to start their projects; Catherine's old friend has a shocking idea for Catherine and Jackson; Meredith treats a returning patient who inspires her project.
Maggie's relationship with Clive starts to progress; she invites him over for a game night to meet Meredith and Amelia; Meredith and Jo meet with the owner of the patent to the polymer they need for their project, who is a friend of the family.
An agent from U.S. Immigration and Customs Enforcement searches the hospital for an employee; Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently; Arizona treats Matthew Taylor's baby.
Crisis management is brought in to help Grey Sloan sort out allegations against Harper Avery; Alex and Jo are thrown for a loop when Nurse Olivia shows up with her son; Arizona spends more time with Sofia.
Alex and Jo go on a road trip to Iowa to find Alex's mom, whom he hasn't heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention, and Jackson works to rebuild the foundation after its reputation is threatened.