Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire and the doctors are introduced to a few new faces that spice things up around the hospital.
Amelia confronts a difficult situation; Meredith deals with the fallout from her conversation with Nathan; Maggie finds herself at an awkward family dinner; Jackson receives big news; Richard and Bailey search for the stars of tomorrow.
April is in charge of the new surgical innovation contest; the doctors are eager to start their projects; Catherine's old friend has a shocking idea for Catherine and Jackson; Meredith treats a returning patient who inspires her project.
Maggie's relationship with Clive starts to progress; she invites him over for a game night to meet Meredith and Amelia; Meredith and Jo meet with the owner of the patent to the polymer they need for their project, who is a friend of the family.
An agent from U.S. Immigration and Customs Enforcement searches the hospital for an employee; Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently; Arizona treats Matthew Taylor's baby.
Crisis management is brought in to help Grey Sloan sort out allegations against Harper Avery; Alex and Jo are thrown for a loop when Nurse Olivia shows up with her son; Arizona spends more time with Sofia.
Alex and Jo go on a road trip to Iowa to find Alex's mom, whom he hasn't heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention, and Jackson works to rebuild the foundation after its reputation is threatened.
One of Grey Sloan Memorial's own is seriously injured, making the team reflect on what is truly important to them. Meanwhile, Nicole Herman pays a visit to GSM and talks to Arizona about an exciting opportunity.