The detectives work on two cases. One involves multiple homicides at a restaurant. The second case opens with an amputated leg found in a dumpster and ultimately leads to the owner of the missing limb, found dead in his own bed.
A suspicious brief case is found at a mercantile marker and a bomb squad is immediately summoned to the scene where Dectective Taylor is using a robot to lift a fingerprint off of it. Meanwhile, an apparent suicide takes place at a church.
A police officer is shot in the middle of Central Park from a building way outside the park. He dies right away. Sadly, the bullet, an important piece of evidence, is buried into the officer's horse, Blue. Removing might end Blue's life.
Mac and Stella investigate the murder of a woman who was stabbed in the heart with a wooden stake. The police arrest a woman who was kneeling over the body with blood on her, but Mac isn't convinced that she committed the crime.
A young John Doe, nicknamed 'Slick', is found lying across the rails of an underground subway. At first, he appears to have died from third-rail electrocution, but an autopsy suggests that he may have met his end by other means of electrocution. Meanwhile, Leo Whitefield is found shot dead at close range in a gallery he owns, with no sign of break in or theft, and a construction worker turns up with a fatal injury to the head.
The detectives investigate a murder at a grocery store that is also connected to the death of a young man with the tattoo "Tanglewood" on his back. A third case involves a woman who was killed in a hit-and-run auto accident.
A very small box is found on the beach with the body of a man curled nicely in it. What is amazing is that this box is only 2x2x2 feet. This leads the detectives to a circus where the man was working as a contortionist.
A body is found, wrapped in a hotel sheet, at a laundry facility prompting Taylor and Bonesara to go through a list of NY hotels to find the owner of the sheet. Messer and Burn investigates the death of a 'living statue' found in a local park against Taylor's order.
A beautiful young sports agent is struck accidentally by truck as she flees from an unknown abuser. Meanwhile, a Boston baseball fan turns up dead from internal injuries and a new confession leads Mac to reopen the case of a death row inmate helped convict.