| Cast overview, first billed only: | |||
| Freddie Prinze Jr. | ... | Fred | |
| Sarah Michelle Gellar | ... | Daphne | |
| Matthew Lillard | ... | Shaggy | |
| Linda Cardellini | ... | Velma | |
| Seth Green | ... | Patrick Wisely | |
| Peter Boyle | ... | Old Man Wickles | |
| Tim Blake Nelson | ... | Jacobo | |
| Alicia Silverstone | ... | Heather | |
| Neil Fanning | ... | Scooby-Doo (voice) | |
| Pat O'Brien | ... | Self | |
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Bill Meilen | ... | Chauffeur |
| Zahf Paroo | ... | Ned | |
| Chris Gauthier | ... | Daphne's Tattooed Fan #1 (as Christopher Gauthier) | |
| Peter New | ... | Daphne's Tattooed Fan #2 | |
| Morgan Brayton | ... | Mullet Nerdette #1 | |
When Mystery, Inc. are guests of honor at the grand opening of the Coolsville Museum of Criminology, a masked villain shows up and creates havoc before stealing the costumes of the gang's most notorious villains: Black Knight Ghost, Pterodactyl Ghost and Tar Monster. Could it be that their nemesis, mad scientist Jonathan Jacobo has returned and is trying to recreate their deadliest enemies? Velma has a crush on the museum curator Patrick Wisely despite her fears of intimacy but why is he acting so suspicious? The Mystery Gang is hard pressed to succeed this time, since annoying television reporter Heather Jasper-Howe insists they are buffoons. Written by Mattias Thuresson
This was a lot of fun, another great version of the old cartoon favorite. I really enjoy how much work is put into these adaptations of cartoons. Matthew Lillard as Shaggy is as always a favorite of mine, but, in this particular movie, Velma was just about as good. Plus as an added bonus, she actually looked hot for the first time. It was also good to see Seth Green in a very different role than in his previous works. Hats off to Sarah Michelle Gellar for another great performance as Daphne. I also enjoyed seeing Peter Boyle, who of course was in Young Frankenstein as the monster. He always works in these types of films. I give this film a 7 out of 10. See this at any price!