A young, single mother who is struggling to make ends meet goes missing after dropping her son off at the babysitter. While the team struggles to find out what they can about the young woman's personal life, Sam feels the case is hitting very close to home. They soon learn of a drug smuggling gang and an ex-con who is connected to other unusually similar cases of missing women. The team plans to bust him on every charge possible, but at a very dangerous price.
Sam volunteers to go undercover to bust a ruthless drug smuggling ring, which the team believes is directly connected to the disappearances and murders of different women. Sam's difficult past is revealed, and despite warnings to get out, she becomes dangerously involved in her undercover investigation, which quickly turns into a life-or-death hostage situation.
Jack and the team search for Peter Dusek, a wealthy, 72-year-old murder trial juror, whose disappearance could cause a mistrial. Although the agents initially suspect that the defendant may have orchestrated Peter's disappearance as a means of forcing a mistrial, they soon wonder if the juror disappeared of his own volition, since he tried to recuse himself with a note from his cardiologist the day after the defendant threatened a witness in the courtroom.
As part of the child custody battle, Jack endures a lengthy, brutal deposition by his wife's divorce attorney, during which his wife, Maria, unexpectedly arrives. Maria's cutthroat lawyer uses Jack's childhood traumas, his past affair with Samantha and his dedication to his job against him.
Jack and the team investigate the disappearance of a 12-year-old autistic boy who ran away during a class trip to a museum. His father, Daniel Norville, chaperoned the outing. Jack is suspicious of Daniel, who was seen yelling at the boy before he went missing.
Jack and the team investigate the disappearance of Rosie Diaz, a postal employee. When her truck is found abandoned and emptied of the $12,000 worth of video games Rosie was delivering, the team wonders whether she is a victim of foul play or a willing participant in the theft.
Jack and the team investigate the disappearance of Chelsea Prince, a 23-year-old society girl known for her constant partying and headline-grabbing escapades. Her badly beaten limousine driver recounts how the limo was ambushed and Chelsea was taken.
Martin is wracked with guilt when he fails to prevent Mike (MASAM HOLDEN), a 12-year-old boy, from being dragged into a car outside of the boy's school. Encouraged by Martin's description of the kidnapper, Brian Stone (DYLAN BAKER - "The Elizabeth Smart Story," "Kinsey"), and his vehicle, the team tries to ease Martin's anguish over failing to stop the boy's abduction, even though he jogged by Mike and the kidnapper just moments before the crime occurred.
Jack and the team investigate the disappearance of Stephanie, a singer in a church choir. Stephanie's choir director informs the agents that the missing woman had been unusually emotional at the last choir practice and requested to perform a particular hymn on Sunday but then failed to show up to sing it.
Vivian takes time off from work to deal with her health problems and tries to act brave before her family and colleagues. Her deeply concerned team members attempt to focus on their case of a missing psychic, Agnes (ALEXANDRA LYDON - "24").
When a 13-year-old girl goes missing after choosing to investigate the age-old murder of a different teenage girl - taking suspicion off of the original suspect and placing it on her own father instead - the team races against the clock to find out what happened to Daisy and if her father, who turns out not to be so innocent, truly plays a part in both his daughter's disappearance and of the murder of Amber Bryce, a years-ago unresolved case.
The team helps Danny search for his missing, estranged brother, Rafael "Rafi" Alvarez (ALEX FERNANDEZ), a recovering drug addict and ex-convict who Danny grimly suspects may have lapsed into his illegal and destructive past habits.
An old man estranged from his wife and two daughters goes missing after last being seen ready to jump from the roof of his building. Jack gets personally involved in the case and trying to find the man.
As Vivian undergoes open-heart surgery, Jack and the team search for a missing woman who may be the innocent victim of an identity theft ring. But further investigation reveals that she is linked to international terrorists plotting the assassination of a foreign dignitary.