The show was originally broadcast live. In 2004, due to increasing concerns about offending local affiliates, the show began taping an hour before airtime, so network executives can vet it before it goes to air.
On August 21, 2012, ABC announced that Jimmy Kimmel Live! (2003) would be moved from 12:00 a.m. to 11:35 p.m., putting the show up directly against "The Tonight Show" and "The Late Show", for the first time since its debut. "Nightline" would be moving to 12:35 a.m. after Jimmy Kimmel Live! (2003). The change went into effect in January 2013.
The May 1st, 2017 broadcast was the first episode to air since Kimmel went on temporary hiatus for the birth of his son William who was born with the heart defect TOF. Kimmel gives an emotional monologue explaining his son's condition Kimmel's guests that night were cardiac surgeon Dr. Mehmet Oz who explains the condition and snowboarder Shaun White who himself also suffered TOF.