A man is taken to a small clinic in Guam with mysterious bites on him. This sparks a search for what could have caused such wounds. A group of men and women fly to the island he lived on to investigate the situation. Due to technical problems, their small plane crashes and they are stranded on the island. After some time, they come to find the man's village is empty and that strange new breeds of killer arachnids have appeared all about the forest.
After a man dies in a Guam from a mysterious syndrome caused by an unidentified insect-bite on a nearby tiny island, an expedition team heads for the jungle to investigate. It comprises medical and zoological scientists as well as security, headed by Valentine, plus their female pilot. they soon discover it's not an insect but a huge, spider-like mutated monster which kills people, both locals and them, by bite or poison.
- A secret expedition, to a South Pacific island, is searching for an unknown deadly virus. Loren Mercer, ex-Navy pilot, is in the South Pacific looking for her ex-boyfriend, Captain John Lightfoot; who disappeared while on a secret mission. What Mercer doesn't know is that Lightfoot collided with an alien spacecraft that discharged biological material all over the island that they are heading for. The mortal virus seems to be transmitted by what the natives call a "very large" spider. As the scientific expedition makes its way to the other side of the island, it becomes obvious that it has turned into a tasty dish for the bloodthirsty giant-spider with a vicious killer instinct. Before they can save the world, they must try to save themselves!...