Andy finds herself in a battle with her father over his independence after he is diagnosed with a degenerative nerve condition; Lu tries to figure out how a pregnant woman is responsible for the deaths of her infant children.
When Lu's mentor misdiagnoses a patient, Lu contemplates whether or not to tell her that she needs to retire; Andy treats a couple's two young daughters who are diagnosed with a rare genetic disorder; Andy's daughter, Jesse faces bullying over her back brace.
After Mickey is shot by a mentally ill patient of Lu's, Lu faces a difficult decision whether or not she should keep him on life support or donate his organs to be transplanted; Andy treats a woman who is in need of a heart transplant and tries to help out the parents of a infant son who has a genetic disease.
Andy treats a TV chef with a suspicious rash; Lu questions her beliefs about the death penalty when she is asked to testify on behalf of Mickey's murderer and is suspicious when her neighbor is found deceased.
Lu suspects that a young girl's asthma is caused by the stress of her bickering parents; Andy suspects her nanny of theft which turns out to be orchestrated by her daughter Lizzie who was trying to get her parents back together.
In the middle of a crushing heat wave, Andy is confronted with the ethical dilemma of whether to help a single woman, pre-destined to have early Alzheimer's disease, have a baby. Also, Lu fights to save a sixteen-year old girl who has been shot in a gang initiation and finds out the truth about a mother who turns in her daughter with Downs Syndrome as the perpetrator of the shooting. Andy struggles with introducing Dr. Milo Morton to her daughters. Elsewhere, Andy and Milo stop a baby's heart in the fight to save its life.
Andy fights for the rights to an organ from a liver transplant; Lu helps out a woman whose husband has just been released from prison; Nick treats a paramedic who was stuck with a needle from a drug addict.
Andy and Lu's patients both show signs of being poisoned. It appears their exposure to chemicals may have more to do with where they shop. Lu tries to mediate between an alcoholic and daughter offering a piece of her liver for transplant.
When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.