Arquette, born Robert Arquette, worked as an actress since age 12, earning roles in the Bride of Chucky, The Wedding Singer, Of Mice and Men and more.
Celebrities who worked with Arquette over the years are sending their remembrances.
"Alexis was a one of a kind genius, who appeared on my sitcom and on the Roseanne talk show," Roseanne Barr tells People. "Alexis was a brilliant and hilarious talent and will be deeply missed. My sincerest sympathy to the Arquette family