In the scene where Willy Jack Pickens (Novalee's estranged baby's father) picks up an underage hitchhiker Jolene he ask, "Where are you going"? She responds, "Anywhere but here". This is a nod to Natalie Portman previous movie Anywhere But Here.
The trivia item below may give away important plot points.
Five (5) is Novalee's unlucky number. When Novalee is going into labor in Wal-Mart she walks down aisle 5 that has a giant price tag of $4.96. Though the aisle 5 reference is obvious, 49 plus 6 equals 55.