The premise is that of a sick and twisted after school special from hell where all of the wrong lessons are learned. (Great one from Jellineck `if you're going to smoke marijuana you have to be prepared to spend a lot of time laughing with your friends').
It is one of the smartest, subversive and exhilaratingly un-pc shows ever. It a makes fun of authority figures, the handicapped, minorities and that's just for starters. Each episode is crammed with one-liners and sight gags so numerous they'll make your head spin.
It's all in the delivery, folks. Principal Blackman (Gregory Hollimon), Noblet (Steven Colbert) and Jellineck (Paul Dinello) are all pitch perfect. In the hands of lesser talents these jokes would fall flat. The show has huge laughs. The entire Hit & Run episode comes to mind, as does the scene in The Virgin Jerri when Drake removes Jerri's toe separator from her filthy feet and sniffs it lustily or when Jerri recites the poem Packing a Musket to the class.
I could go on and on but just trust me - you HAVE to watch this show.