The idea of the reapers having stingers coming out of the mouth were inspired by polish folktales where the vampires had a stinger or "finger" coming out of the mouth that they used to suck blood rather than use teeth like the Balkan genus that is the greatest influence on the modern vampire mythology.
When Damaskinos mentions the virus that causes vampirism, he says "parvovirus", though the closed captioning says "horrible virus" because of the obscurity of the term. Parvovirus IS a true virus type, and meets all the requirements for creating vampires in a fictional environment. The term was too obscure for most people to recognize, other than experts in virology.
Pop Icon Michael Jackson was originally going to have a cameo in the "House of Pain" sequence as a "Vampire Pimp" that Nyssa encounters as she searches the upstairs hall. Jackson had to drop out due to scheduling conflicts and the part was played by a Czech actor. The sequence was ultimately cut out entirely for pacing reasons.
Wesley Snipes was not always available for each day of filming for this movie, which came out in 2002. During 2002, Wesley starred in 3 other films aside from Blade 2. Instead of waiting for Wesley to become available, the crew shot another actor (who was not Wesley's stunt double) for scenes where it was not necessary to see Wesley's face. The first scene being where Blade, Scud. and Nyssa are riding in the helicopter to meet Damaskinos. The second was after Nyssa performed an autopsy on the dead reaper and confronts Blade in his quarters about his attitude toward the Bloodpack.
During the fight with Nomak in the church part of the House of Pain, the stained glass window is a replica of Dr. Strange's (another Marvel character who battles the occult) medallion, The Eye of Agamotto.
In the scene before while entering the vampire club with the Bloodpack, a large neon sign can be seen on top of a building that says, in large red letters, "Radoo". The history of Vlad the Impaler (whom the legend of Dracula is largely based upon) talks of his brother Radu. This name is also often associated with vampire movies as it is deeply ingrained in the Dracula story.
The look of Damaskinos is based off Nosferatu and the idea of his skin looking like old marble. The look for Nomak and the Reapers were based off numerous incarnations of drawings by Guillermo del Toro and concept artists, but primarily based off the mutants from Beneath the Planet of the Apes (1970).
David S. Goyer's original idea was to use Morbius as a primary villain, but Marvel decided they wanted to retain the rights to make an entirely separate franchise out of Morbius - i.e. a Morbius film, so the story was changed slightly and Jared Nomak was created to be used as the primary villain instead.
The early scene in which Scud is watching The Powerpuff Girls (1998) was originally written with him watching an episode of Speed Racer (1967). However, the owners of the domestic rights wouldn't allow it.
According to Wesley Snipes on the commentary with Goyer, there were four fight choreographers: Donnie Yen, who choreographed the "wire fu-esque" sequence with Blade and Nomak in the cathedral in their first fight; Jeff Ward; Clay Fontenot; and Snipes himself. Goyer remarked that there was a "wonderful rivalry" between Yen and Ward/Snipes/Fontenot.
In the DVD commentary, Guillermo del Toro said he paid homage to Dr. Manhattan from Watchmen and the book I am Legend. A reaper explodes similarly to the way Dr Manhattan explodes and the heroes were bombarded by reapers, much like the zombies bombardment in I am Legend.
Nyssa use's two Sa Vs. 61 Skorpion's. Reinhardt- two heavily customized Beretta 92fs with blade modifications,and a Remington 870 marine magnum "Stake gun". Asad-colt model 727 fitted with an M203 grenade launcher. Chupa-M16A2. Priest-Colt Double eagle. Verlaine- Heckler & Koch MPK5. Lighthammer- Heckler & Koch MK 23 Mod 0.
Blade himself wears Oakley Four sunglasses, the ninja-style vampires who descend near the start of the film to offer Blade a truce are wearing heavily modified Oakley Overthetops, Reinhardt sunglasses are Oakley Square Wires and a further appearance can be seen fleetingly being worn by the fat, bearded vampire towards the end of the film, he is wearing Oakley Mars. All these appearance of Oakley sunglasses throughout of the film are apparently down to Wesley Snipes being big fan of the brand though his sunglasses in Blade (1998) were a pair of BlackFlyz.
When Rush takes Blade to the place where Wistler is held, he speaks "vampire language" through the door for the other one to open. He clearly says "Torrentetres" which is a reference to the Spanish film Torrente 3: El protector (2005) which was in production at the time, and which was directed by Santiago Segura (actor who portrays Rush).
The clock seen on the back wall of Damaskinos' lair is a reproduction of the Orloj, or astronomical clock of the city of Prague. It's purpose is not only to tell the time but also to show the Earth's position relative to the sun, moon and the cosmos.
Reinhardt (Ron Perlman) exposes his gloved hand to a beam of sunlight and it burns his skin regardless of the protection of the glove. In the first Blade movie Deacon Frost (Steven Dorff) and crew go into the sunlight with leathers and make up with no ill effects from the sun.
David S. Goyer and Peter Frankfurt both admired director Guillermo del Toro and believed his dark sensibilities to be ideal for Blade II. Frankfurt first met del Toro when Frankfurt's design company, Imaginary Forces, did the title sequences for Mimic. "I admired Mimic and got to know Guillermo through that film," says Frankfurt. "Both David Goyer and I have been fans of his since Cronos (1993) and were enthusiastic about him coming on board. Guillermo is such a visual director and has a very strong sense of how he wants a movie to look. When you sign on with someone like Guillermo you're not going to tell him what the movie should look like, you're going to let him run with it." Like Goyer, del Toro has a passion for comic books. "Guillermo was weaned on comic books, as was I," says Goyer. "I was a huge comic book collector... my brother and I had about twelve thousand comic books that we assembled when we were kids, so I know my background." Tippett Studio provided computer-generated visual effects, including digital doubles of some of the characters, while Steve Johnson and his company XFX were hired to create the prosthetic makeup and animatronic effects. Del Toro chose not to alter the script too much from the ideas created by Goyer and Snipes. "I wanted the movie to have a feeling of both a comic book and Japanese animation," said the director. "I resurrected those sources and viewed them again. I dissected most of the dailies from the first movie; I literally grabbed about four boxes of tapes and one by one saw every single tape from beginning to end until I perfectly understood where the language of the first film came from. I studied the style of the first one and I think Norrington used a tremendous narrative style. His work is very elegant."
Stepping back into Blade's shoes was a challenge Wesley Snipes relished. "I love playing this role. It's fun as an actor to test your skills at doing a sequel, to see if you can recreate something that you did," Snipes says. Peter Frankfurt adds, "Wesley is Blade; so much of the character was invented by Wesley and his instincts are so spot on. He takes his fighting, his weapons and attitude very seriously. He's incredibly focused, but he's also very cool and fun." "Wesley knows Blade better than David Goyer, better than me, better than anyone else involved in the franchise," adds Guillermo del Toro. "He instinctively knows what the character would and wouldn't do, and every time he twists something around, something better would come out."
Wesley Snipes: [Sun Tzu] Snipes' quoting of Sun Tzu - "Keep your friends close, and your enemies closer," follows references to the works of Sun Tzu in many other Snipes movies including Passenger 57 (1992), Rising Sun (1993) and The Art of War (2000).
The final scene, where Blade hides behind the Bunny Booth glass waiting for his victim (Rush), is incredibly similar to a scene in The Crow: City of Angels (1996) where the crow does the same. Both movies have many similarities in set-pieces and costume design, yet this scene is almost identical in both films. It's plausible to concede that after the critical and financial failure of this first Crow sequel, David S. Goyer could include this scene without scrutiny; having written both films as well.