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Osmosis Jones (2001) Poster

(2001)

Trivia

Jump to: Spoilers (2)
Warner Bros. Feature Animation was in serious financial trouble during the film's production, and in 2000 it came down to two options: green-light another film by Brad Bird, who made the critically acclaimed film The Iron Giant (1999), or this film. Warner executives chose this film over Bird's, and upon learning this Bird got so mad that he took his film with him to Disney and Pixar. That film would become the highly successful The Incredibles (2004), whereas this film bombed at the box office, was critically panned, and ultimately killed Warner Bros. Feature Animation.
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The population of the City of Frank is 78,899,293,934,872,302,829,287,438.
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Bill Murray's character mentions a "National Chicken Wing Festival" in Buffalo, New York. While the festival did not exist during the filming of the movie, this mention caused organizers to create an annual festival in Buffalo.
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The last 2D animated feature film released by Warner Bros. pictures, and the final film of Warner Bros. feature animation up until Teen Titans Go to the Movies (2018).
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According to filmmakers, Mayor Phlegmming is based on Richard Nixon and Tom Colonic is based on John F. Kennedy. William Shatner played Phlegmming accordingly.
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At 01:01:04 into the movie, Osmosis Jones walks into the Chief's office and says "Brandy! I mean, Leah. Why are you here?" He is speaking to the mayor's aide Leah, who is voiced by Brandy Norwood. The flubbed line was acted so well that it was left in because it felt pleasingly funny.
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Although Thrax is considered to be a dangerous virus, it is never clarified throughout the film what type he is.
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In the bladder sequence, you can see one of the characters carrying the Pokemon character Pikachu as a pet.
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Kidney Rock, the band playing at The Zit, is rapper Kid Rock and his back-up band, including rapper Joe C., who died shortly before the film's release this film was dedicated to his memory.
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Early in the movie, Thrax is called "La Muerte Roja" (The Red Death), name of the killer plague in Edgar Allan Poe's short story "The Masque of the Red Death".
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The name of the song that Thrax keep humming is called "Fever".
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The signs in Franks body read "Slow - Sore Throat", "Ulcer Repair", "Danger - Open Nerve" and many more like it. In the stomach, Arrivals signs like "Booger" can be seen.
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Bill Murray and Chris Elliott's first time onscreen together since Groundhog Day (1993).
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The dreams that Frank has in the order they are seen are: "Honey, I forgot my pants"; "The Exam" with disclaimer "He didn't study... and the test is in five minutes!"; "Your Worst Nightmare" with Uncle Bob marrying Shane; "Girls from the bus stop".
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Will Smith was interested in the role of Ozzy, but was unable to do the part due to scheduling conflicts.
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The raindrops outside the news stand look like sperm cells.
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WILHELM SCREAM: Heard when Thrax (after kidnapping Leah) hijacks a vehicle and throws out the driver.
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Nerve News Network (NNN) is a parody of Cable News Network (CNN), especially in its logo. CNN is owned by TimeWarner, the same media conglomerate that owns Warner Bros., the major Hollywood film studio that produced this movie.
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Chuck Norris, LeVar Burton, Samuel L. Jackson, Tom Cruise, Billy Bob Thornton, Robert Downey Jr., Kurt Russell, Kevin Grevioux and Mike Myers were considered for the role of Thrax.
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Malcolm McDowell, Tim Allen, Dwayne Johnson, James Marsden, Billy Bob, Doug Jones, Keanu Reeves and Leslie Nielsen were considered for the role of Drix.
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Alex Winter, Cuba Gooding Jr., David Spade, Harry Enfield, Ryan Reynolds, Chris Tucker, Warwick Davis, Tom Green, Rowan Atkinson and John Leguizamo were considered for the role of Osmosis Jones.
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Dan Aykroyd, Tom Hanks, Ben Miller and Johnny Depp were considered for the role of Frank Detorre.
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Sherri Howard, Holly Robinson, Camryn Manheim and Paula Abdul were considered for the role of Leah.
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Kathy Najimy, Amanda Detmer, Sophie Marceau and Jada Pinkett Smith were considered for the role of Mrs. Boyd.
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Brian Murray, Gregory Peck, Colm Meaney, Alan Cumming were considered for the role of Major Phlegmming.
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Matt Frewer were considered for the role of Tom Colonic.
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Peter Greene, Donald Sutherland, George Hamilton, Jeremy Irons, Hugh Grant, Matthew Modine and Ciarán Hinds were considered for the role of Bob Detorre.
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Frank says the Buffalo Wing Festival has 99 kinds of wings and 128 different dipping sauces. This amounts to 12,672 different ways to pair wings and dipping sauces.
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Anthony Anderson were considered for the role of Osmosis Jones.
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Bryan Brown were considered for the role of Drix.
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Julie Benz were considered for the role of Leah.
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Martin Short were considered for the role of Osmosis Jones.
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M.C. Gainey were considered for the role of Tom Colonic.
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Patrick Stewart were considered for the role of Thrax.
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Steve Guttenberg were considered for the role of Frank Detorre.
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Eric Roberts were considered for the role of Mayor Phlegmming.
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Jeffrey DeMunn were considered for the role of Bob Detorre.
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Ally Sheedy were considered for the role of Mrs. Boyd.
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Charles Nelson Reilly were considered for the role of Tom Colonic.
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Virginia Madsen were considered for the role of Mrs. Boyd.
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Paul Sorvino were considered for the role of Drix.
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Dennis Farina were considered for the role of Thrax.
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Reese Witherspoon were considered for the role of Leah.
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Ernest Borgnine were considered for the role of Mayor Phlegmming.
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Annette Bening were considered for the role of Mrs. Boyd.
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Todd Stashwick were considered for the role of Osmosis Jones.
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Will Patton were considered for the role of Drix.
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Isaac Hayes were considered for the role of Thrax.
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Christopher Atkins were considered for the role of Frank Detorre.
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Spoilers 

The trivia items below may give away important plot points.

The screenplay for Osmosis Jones was based on a nightmare had by Jupiter Bar co-owner Jeff Rogers.
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Since the collapse of the dance club The Zit, was also named The Cyst and in development period.
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See also

Goofs | Crazy Credits | Quotes | Alternate Versions | Connections | Soundtracks

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