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Osmosis Jones (2001)

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A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.


Marc Hyman
3,609 ( 1,051)
1 win & 8 nominations. See more awards »





Cast overview, first billed only:
Chris Rock ... Osmosis Jones (voice)
Laurence Fishburne ... Thrax (voice)
David Hyde Pierce ... Drix (voice)
Brandy Norwood ... Leah (voice)
William Shatner ... Mayor Phlegmming (voice)
Ron Howard ... Tom Colonic (voice)
Kid Rock ... Kidney Rock (voice)
Kenny Olson Kenny Olson ... Kidney Rock (voice)
Jason Krause Jason Krause ... Kidney Rock (voice)
Joe C. ... Kidney Rock (voice)
Stefanie Eulinberg Stefanie Eulinberg ... Kidney Rock (voice)
Jimmie Bones Jimmie Bones ... Kidney Rock (voice)
Uncle Kracker Uncle Kracker ... Kidney Rock (voice)
Jonathan Adams ... Additional Character Voice (voice)
Carlos Alazraqui ... Additional Character Voice (voice)


Frank Detorre is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by Anthony Pereyra <hypersonic91@yahoo.com>

Plot Summary | Plot Synopsis


Every Body Needs A Hero. See more »

Motion Picture Rating (MPAA)

Rated PG for bodily humor | See all certifications »

Parents Guide:

View content advisory »






Release Date:

10 August 2001 (USA) See more »

Also Known As:

Agent Bílá krvinka See more »

Filming Locations:

Plymouth, Massachusetts, USA


Box Office


$70,000,000 (estimated)

Opening Weekend USA:

$5,271,248, 12 August 2001, Wide Release

Gross USA:

$13,596,911, 7 October 2001
See more on IMDbPro »

Company Credits

Show more on IMDbPro »

Technical Specs


Sound Mix:

DTS | Dolby Digital | SDDS


Color (Technicolor)

Aspect Ratio:

2.39 : 1
See full technical specs »

Did You Know?


Leslie Nielsen were considered for the role of Drix. See more »


When Shane decides not to go to Buffalo with Frank, we see the ticker above his door showing the scores of various sports games. The item "Seattle: 5 Oakland: 4" scrolls onto the screen in two consecutive shots. See more »


Osmosis: That's Chill, he's a flu shot.
Drix: Funny. He doesn't look fluish.
See more »

Crazy Credits

The title appears as bubbles, which then pop after 5 seconds. See more »

Alternate Versions

Gonad's Gym logo appears on Drix's suitcase during a scene in police station locker room. In an earlier "cut" of the film, Ozzy and Drix visit an amusement park behind Frank's eye, called "See World". See more »


Spoofs Entertainment Tonight (1981) See more »


Big Ball
Written by T. Cook and Jazze Pha
Produced by Jazze Pha
Performed by Drama
Courtesy of Atlantic Recording Corp.
See more »

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User Reviews

Good film but has it's flaws
13 March 2013 | by bazmitch23See all my reviews

When you mention the title of this film to someone, they just look at you and say "What?".

Yeah, nobody went to see this film when it came out. I think it's because how do you market a film like this? Since this takes place in the human body, there's all kinds of gross out humour in it. Some of it is too much for a PG rated film.

That's my biggest problem with this film and why it wasn't marketed very well. It's gross. The scene where the nose dam breaks and a giant tidal wave of snot comes out is not what you're mean to see in a family film. Especially on the big screen. The scene where Frank vomits on the teacher and it is shown in a newspaper headline, we actually see the vomit. You don't show people vomiting in a PG film. Not only that, but it's part of the story. Making gross out gags part of the story is not a good idea.

Also, the scene where the zit is ready to pop, we get a big giant close up on it which is enough to make anyone cringe.

It's almost like Panty and Stocking with Garterbelt. A show loaded with gross out humour. But that was for adults. This is meant to be a family film.

Now, the stuff I do like about it; the animation is great, it's very creative, (making the stomach the airport, the brain is city hall, the armpits are the steam room, I could go on)Laurence Fishburne was fantastic as Thrax. I kept forgetting it was him. Even if you don't like this film, you have to admit, Thrax is awesome. The music's great too. I like all the body puns as well.

Not a film for everyone, but has gained a cult following on DVD.

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