Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ...Written by
Anthony Pereyra <email@example.com>
Warner Bros. Feature Animation was in serious financial trouble during the film's production, and in 2000 it came down to two options: green-light another film by Brad Bird, who made the critically acclaimed film The Iron Giant (1999), or this film. Warner executives chose this film over Bird's, and upon learning this Bird got so mad that he took his film with him to Disney and Pixar. That film would become the highly successful The Incredibles (2004), whereas this film bombed at the box office, was critically panned, and ultimately killed Warner Bros. Feature Animation. See more »
When Shane decides not to go to Buffalo with Frank, we see the ticker above his door showing the scores of various sports games. The item "Seattle: 5 Oakland: 4" scrolls onto the screen in two consecutive shots. See more »
Hey, partner, what you got there?
Oh, these? These are polluted oysters. Well, they WERE polluted. I replanted them in six weeks ago. That's how long the state says you gotta do it for. And every time the tide came in, it flushed all the bad stuff out.
Can you eat 'em?
Well, if my hypotenuse is correct...
sure. Y-y-yeah, definitely.
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
The stand-out comedy of 2001- someone has a big imagination
Whoever made this has a big imagination about what goes on inside the human body. It's very witty and smart. The whole rookie cop cliche who messes up and is THIS close to being pulled off the force and has a hunch a teams up with an unlikely buddy and ends up being right (for example, Rush Hour) is being given a whole new twist. The Farrley Brothers have done it again- and made a solid B+ stand out comedy. B+, 8/10
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