Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ...Written by
Anthony Pereyra <firstname.lastname@example.org>
The raindrops outside the news stand look like sperm cells. See more »
When Osmosis comes back from "The Zit" he greets Leah by saying "Brandy- oh I mean Leah". Brandy Norwood was the voice of Leah. The error was left in because it was acted so well and was funny. See more »
We were so poor, we lived off peanut butter and cellulite sandwiches! You ever try to blow-dry your hair with a fart?
OK, I get it. You were poor.
You bet I was! You ever try to make a snowman out of toilet paper cling-ons? Now that's poor!
OK, please, you're going to make me vomit!
Vomit? We couldn't afford no vomit; that's for rich folk.
Excuse me while I wipe my eyes.
Oh, you wanna talk about wiping?
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The opening credits are shown on strands on amoeba. See more »
Okay, I think I've found the Sadly Underrated Movie of the Year.
I think that, between this and "the Iron Giant", Warner Brothers Animation has GOT to spring for a better promotion department. Really, all they'd have to say is something like: "We just let the creators of 'Something About Mary' and 'Dumb and Dumber' make their own cartoon. Brace yourselves."
All complaints aside, and none of them are really the movie's fault, this is one of the most inventive animated films I've seen in a very long time. The characters and backgrounds are allowed to look and move in ways that are downright refreshingly bizarre. The visuals are very imaginative. The humor, while funny, is still very much what you'd expect from a Farelly Brothers movie that takes place inside a very sick man, so I wouldn't recommend it to little kids or the weak of stomach. If you have a little future A+P major, however, this is going to blow their mind. Give it a look!
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