Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
The population of the City of Frank is 78,899,293,934,872,302,829,287,438. See more »
During the beginning when Ozzy is patrolling the mouth in a helicopter, there is a shot where some of the bubbles of egg and saliva very quickly shift position. This is likely an animation error. See more »
Hey, Ozzy, can I count on you to keep Frank in shape? You know we've got that big insurance exam next month.
I don't know. You'll have to talk to my new parter... if he feels like hanging around for a while.
But my work visa has expired.
Well, we'll go down to the hemorrhoid and get you a good lawyer.
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
Osmosis Jones is a comedy of human proportions, I guess. It works enough and when it works well it's a good movie. Although when you think about it the plot-line inside Frank's body (frank is played by Bill Murray with no shame in great form) is rather routine and for me was the only thing keeping this from being really good.
Still, it might be a worthwhile movie, more for kids than adults, but it it watchable for all. Various voices include Chris Rock, Brandy Norwood, Laurence Fishburne, David Hyde Pierce and William Shatner. Pleasant most of the way and sometimes cool. B
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