Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ...Written by
Anthony Pereyra <firstname.lastname@example.org>
Camryn Manheim were considered for the role of Leah. See more »
When Osmosis comes back from "The Zit" he greets Leah by saying "Brandy- oh I mean Leah". Brandy Norwood was the voice of Leah. The error was left in because it was acted so well and was funny. See more »
Yo, where do you think you're going?
To get our cootie.
Looking like that? They'll tear you apart. You gotta get spiffy.
[Osmosis rearranges himself to look like a germ]
Check it out!
Hmm. Flexible cellular dynamics. What an ingenious defense mechanism. Ooh, let me try!
[Drix tries, only succedes in mangling his face]
What do you think?
I think you should guard the car.
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The title appears as bubbles, which then pop after 5 seconds. See more »
Gonad's Gym logo appears on Drix's suitcase during a scene in police station locker room. In an earlier "cut" of the film, Ozzy and Drix visit an amusement park behind Frank's eye, called "See World". See more »
Osmosis Jones is a comedy of human proportions, I guess. It works enough and when it works well it's a good movie. Although when you think about it the plot-line inside Frank's body (frank is played by Bill Murray with no shame in great form) is rather routine and for me was the only thing keeping this from being really good.
Still, it might be a worthwhile movie, more for kids than adults, but it it watchable for all. Various voices include Chris Rock, Brandy Norwood, Laurence Fishburne, David Hyde Pierce and William Shatner. Pleasant most of the way and sometimes cool. B
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