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Title: Osmosis Jones (2001)
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| Cast overview, first billed only: | |||
| Chris Rock | ... | Osmosis Jones (voice) | |
| Laurence Fishburne | ... | Thrax (voice) | |
| David Hyde Pierce | ... | Drix (voice) | |
| Brandy Norwood | ... | Leah (voice) | |
| William Shatner | ... | Mayor Phlegmming (voice) | |
| Ron Howard | ... | Tom Colonic (voice) | |
| Kid Rock | ... | Kidney Rock (voice) | |
 |
Kenny Olson | ... | Kidney Rock (voice) |
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Jason Krause | ... | Kidney Rock (voice) |
| Joe C. | ... | Kidney Rock (voice) | |
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Stefanie Eulinberg | ... | Kidney Rock (voice) |
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Jimmie Bones | ... | Kidney Rock (voice) |
| Uncle Kracker | ... | Kidney Rock (voice) | |
| Jonathan Adams | ... | Additional Character Voice (voice) | |
| Carlos Alazraqui | ... | Additional Character Voice (voice) | |
Frank Detorre is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by Anthony Pereyra <hypersonic91@yahoo.com>
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The Farrelly brothers are dipping into the animation pool. It's colorful and primitive animation. It's pretty good, but that's not really the problem. Surprisingly the problem is Bill Murray and live action stuff.
Frank Detomello is a slob. He eats a hard boiled egg covered with a deadly germ. And we travel inside Frank to see white blood cell policeman Osmosis Jones (Chris Rock) battle evil virus Thrax (Laurence Fishburne) with the help of Drix (David Hyde Pierce).
Bill Murray looks awful as he gets sicker and sicker. I have to ask if we're supposed to laugh at Bill? It's just gross. Not the gross out humor that the Farrellys are known for. It isn't funny at all.
The animated sections are much better. In fact I prefer they cut out the live action stuff. Chris Rock does a good voice. He has good chemistry with David Hyde Pierce's Drix. They need a few more jokes, but I like the City of Frank.