Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <firstname.lastname@example.org>
The last 2D animated feature film released by Warner Bros. pictures, and the final film of Warner Bros. feature animation. See more »
After the explosion of the Zit, Ozzy and Drix go to the Chief's office. Ozzy sees Leah and says "Brandy.... I mean Leah." His mouth is actually saying "Leah." See more »
What is that nasty smell?
Cherry. Wild cherry. Now let her go.
Why? So you can ice me again?
No, so I can!
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
I wouldn't say this is one of the funniest movies I've ever seen, but there is definitely some original comedy here. I thought it was a very inventive story, and quite interesting. What shocked me more than anything about this film is the fact that it was directed by the Farrelly brothers, who also directed "Kingpin", "Dumb and Dumber", "There's Something About Mary", "Me, Myself and Irene", and "Shallow Hal". So this doesn't really fit their profile, but I'm glad to see that they are trying something new.
Like I said, not the funniest movie in the world, but it's good some good stuff in it. If you're a fan of the Farrelly brothers, then you'll probably want to see this film. If you aren't a fan of the Farrelly brothers, then you still may want to see this film, cause it's a little different than their other films. I hope you enjoy the film. Thanks for reading.
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