A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Writer:

Marc Hyman
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Popularity
4,237 ( 307)
1 win & 8 nominations. See more awards »

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Cast

Cast overview, first billed only:
Chris Rock ... Osmosis Jones (voice)
Laurence Fishburne ... Thrax (voice)
David Hyde Pierce ... Drix (voice)
Brandy Norwood ... Leah (voice)
William Shatner ... Mayor Phlegmming (voice)
Ron Howard ... Tom Colonic (voice)
Kid Rock ... Kidney Rock (voice)
Kenny Olson Kenny Olson ... Kidney Rock (voice)
Jason Krause Jason Krause ... Kidney Rock (voice)
Joe C. ... Kidney Rock (voice)
Stefanie Eulinberg Stefanie Eulinberg ... Kidney Rock (voice)
Jimmie Bones Jimmie Bones ... Kidney Rock (voice)
Uncle Kracker ... Kidney Rock (voice)
Jonathan Adams ... Additional Character Voice (voice)
Carlos Alazraqui ... Additional Character Voice (voice)
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Storyline

Frank Detorre is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by Anthony Pereyra <hypersonic91@yahoo.com>

Plot Summary | Plot Synopsis

Taglines:

He's one cell of a guy, and his partner's a real pill See more »


Motion Picture Rating (MPAA)

Rated PG for bodily humor | See all certifications »

Parents Guide:

View content advisory »
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Did You Know?

Trivia

The population of the City of Frank is 78,899,293,934,872,302,829,287,438. See more »

Goofs

During the beginning when Ozzy is patrolling the mouth in a helicopter, there is a shot where some of the bubbles of egg and saliva very quickly shift position. This is likely an animation error. See more »

Quotes

Bob: Jeez, Frank, I'm standing right here. Can you use a tissue?
Frank: I don't have one.
Bob: Well, use your imagination.
Frank: What's that over there?
[Frank swallows his mucus]
Frank: Better?
Bob: Much better.
Frank: I gotta go get her.
Bob: Alright.
Frank: She'll be excited. She'll probably call you.
[...]
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Crazy Credits

The opening credits are shown on strands on amoeba. See more »

Alternate Versions

On some streaming services, the score plays on the soundtrack as opposed to a pop song during the opening scene. See more »

Connections

Spoofs Airplane! (1980) See more »

Soundtracks

Take it to Da House
Written by Funk Boogie, Money Mark, J.V., Trina, Co, Trick Daddy, Charles Bobbitt (as C. Bobbit), Fred Wesley (as F. Wesley), James Brown (as J. Brown), C. Wayne, Harry Wayne Casey (as H. Casey) and Richard Finch (as R. Finch)
Performed by Trick Daddy featuring The Slip-N-Slide Express
Courtesy of Slip 'n Slide Records/Atlantic Records
Contains excerpts from "The Boss" by James Brown, used courtesy of Polydor Records
Under license from Universal Music Enterprises and sampled recording from "Boogie Shoes" as Performed by KC & The Sunshine Band (as K.C. and the Sunshine Band),
included courtesy of EMI Records Ltd. and used under license from Warner Special Products
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User Reviews

 
animation good, but live action gross and boring
28 September 2013 | by SnoopyStyleSee all my reviews

The Farrelly brothers are dipping into the animation pool. It's colorful and primitive animation. It's pretty good, but that's not really the problem. Surprisingly the problem is Bill Murray and live action stuff.

Frank Detomello is a slob. He eats a hard boiled egg covered with a deadly germ. And we travel inside Frank to see white blood cell policeman Osmosis Jones (Chris Rock) battle evil virus Thrax (Laurence Fishburne) with the help of Drix (David Hyde Pierce).

Bill Murray looks awful as he gets sicker and sicker. I have to ask if we're supposed to laugh at Bill? It's just gross. Not the gross out humor that the Farrellys are known for. It isn't funny at all.

The animated sections are much better. In fact I prefer they cut out the live action stuff. Chris Rock does a good voice. He has good chemistry with David Hyde Pierce's Drix. They need a few more jokes, but I like the City of Frank.


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Details

Country:

USA

Language:

English

Release Date:

10 August 2001 (USA) See more »

Also Known As:

Osmosis Jones See more »

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Box Office

Budget:

$70,000,000 (estimated)

Opening Weekend USA:

$5,271,248, 12 August 2001

Gross USA:

$13,596,911

Cumulative Worldwide Gross:

$14,026,418
See more on IMDbPro »

Company Credits

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Technical Specs

Runtime:

Sound Mix:

DTS | Dolby Digital | SDDS

Color:

Color (Technicolor)

Aspect Ratio:

2.39 : 1
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