Frank Detorre is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ...Written by
Anthony Pereyra <email@example.com>
The population of the City of Frank is 78,899,293,934,872,302,829,287,438. See more »
During the beginning when Ozzy is patrolling the mouth in a helicopter, there is a shot where some of the bubbles of egg and saliva very quickly shift position. This is likely an animation error. See more »
Jeez, Frank, I'm standing right here. Can you use a tissue?
I don't have one.
Well, use your imagination.
What's that over there?
[Frank swallows his mucus]
I gotta go get her.
She'll be excited. She'll probably call you.
[...] See more »
The opening credits are shown on strands on amoeba. See more »
On some streaming services, the score plays on the soundtrack as opposed to a pop song during the opening scene. See more »
The Farrelly brothers are dipping into the animation pool. It's colorful and primitive animation. It's pretty good, but that's not really the problem. Surprisingly the problem is Bill Murray and live action stuff.
Frank Detomello is a slob. He eats a hard boiled egg covered with a deadly germ. And we travel inside Frank to see white blood cell policeman Osmosis Jones (Chris Rock) battle evil virus Thrax (Laurence Fishburne) with the help of Drix (David Hyde Pierce).
Bill Murray looks awful as he gets sicker and sicker. I have to ask if we're supposed to laugh at Bill? It's just gross. Not the gross out humor that the Farrellys are known for. It isn't funny at all.
The animated sections are much better. In fact I prefer they cut out the live action stuff. Chris Rock does a good voice. He has good chemistry with David Hyde Pierce's Drix. They need a few more jokes, but I like the City of Frank.
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