After a freak storm, H.E.A.T. ends up in 2022, where monstrous genetically engineered race of creatures called Dragmas had brought extinction to mutated creatures and humans alike. H.E.A.T. must stop this future from ever happening.
A documentary is being made about H.E.A.T. In Miami, they fight a giant mutant mosquito, Skeetera, and eco-terrorist S.C.A.L.E. led by Alexandra Springer who believes monsters are the next stage of evolution and wants to free them all.
Norrzug the Iron Lion, a giant sphinx-like monster was created in ancient times to guard the city of Amon-Ra, but it betrayed its makers. When archaeologists awaken it again in present day Egypt, it attacks oil fields to feed on oil.
A mutated manta ray interrupts the wedding of Elsie's spoiled sister. Elsie sees this as an opportunity to prove herself to her estranged parents who are attending her sister's wedding and think Elsie is a no-good klutz.
A girl named Meg asks H.E.A.T. to find her two brothers who went missing in a silver mine. They find Silver Hydra there, a mutated monster that turns anyone it touches into silver statue and can regenerate itself in seconds.
Armillaria, a giant fungus that sucks amino acids out of living matter, shows up in Michigan. Also, the city of Miami sues H.E.A.T. for damages when their latest battle with a giant mutated vampire bat leaves the city in ruins.
Deep-Dweller, a giant mutated creature that partially resembles a fish and partially a frog, attacks the boats and ships near the coast of New Jersey. A sleazy local promoter unwisely uses this to his advantage.