In "Imaginary Fiend", a new kid at school proves so unpopular with his classmates that he conjures up an imaginary friend, who turns out to be quite destructive. In "Cootie Gras", one of Pokey Oaks' students develops the cooties and everyone in school, even the Powerpuff Girls, are avoiding him. Mojo Jojo uses the situation to his advantage.
"The Powerpuff Girls Best Rainy Day Adventure Ever" It's raining in Townsville and there is no crime or villainy afoot. So the Girls must stay inside and come up with their very own Powerpuff adventure.
"Speed Demon" The Girls accidentally fly the speed of light and when they arrive home, everything has changed. Fifty years have passed and the world has been taken over by Him, since the Girls weren't around to defeat him.
"Something's a Ms." Miss Bellum is acting very strange lately. And she keeps showing up at crime scenes. It turns out that Sedusa is back, has kidnapped Ms. Bellum and has been impersonating her in order to steal money and jewels.
"Fallen Arches" A gang of old-time villains come out of retirement when they discover the town is being protected by little girls. When the Girls realize that they can't fight their elders, they must enlist the best superhero team of the past to save the city.
"Bubble Vision" Bubbles fighting has been really terribly lately and the Professor discovers that she needs glasses. Bubbles is humiliated by these huge, horrible things and never wants to see or be seen again.
"Gettin' Twiggy With It" Mitch is told to take care of Twiggy, the class hamster for the weekend. But the Girls don't trust him and follow him home. When Mitch flushes Twiggy down the toilet, the Girls are about to attack, but Twiggy emerges bigger and badder than ever.
"Three Girls and a Monster" The Girls are once again in a furious battle with a ferocious monster. But Blossom and Buttercup can't agree on how to fight the beast and Bubbles just wants everyone to get along.
"Candy is Dandy" When the Mayor gives the Girls some candy as a thank you for saving the day, the Girls become hooked on the stuff. They make a deal with a local villain to commit crimes just so they can get their treat.