In a scene early in the movie, the two leads are shown sitting in an outdoor location in front of a large rusty globe. This location is in the city of Savannah, although the two characters have not reached Savannah by that point of the story.
The film was initially marketed as a potentially loose remake of Planes, Trains & Automobiles (1987), which was also released through Paramount Pictures. Both films feature similar plots, of a businessman who has to return home in a short amount of time and finds himself under the company of an annoying loudmouth. Although it was never billed as a remake, numerous interviews claimed the material was at least inspired by John Hughes' film.
About a year after the release of the movie, Sandra Bullock actually did survive a plane crash when the corporate jet she was a passenger in skidded off the runway at the Jackson Hole, Wyoming airport. She was not injured in the crash.