A giant lizard has been spotted in the subways and Jameson is willing to pay $1,000 to the photographer who gets the creature on film. Peter turns to his college professor, Dr. Curt Connors, for answers. But not the answers he expects.
Jameson is becoming obsessed with destroying Spider-Man. So he hires a man named Mac Gargan to try out a new scorpion suit, made in the laboratories of Empire State University. But the mutation of the suit begins to turn Gargan into a monster.
Spider-Man is becoming attached to his new suit. But Eddie Brock has framed Spider-Man for the Promethium X robbery. Alaster and Kingpin send Shocker after Eddie to dispose of him. Now, Spidey will begin to see what the suit is really worth.
The symbiote takes over Eddie Brock to give birth to Venom. Now, Spidey must go up against the most dangerous enemy he's ever faced. One who is stronger, more skilled, undetected by his spider-sense, and knows Spidey's true identity.