The widow of a heart attack victim wants to be impregnated with sperm from her husband's body but his parents object to the procedure. A young boy requires brain surgery to remove a tumour. Down in the basement, two medical transcribers plot to sell copies of a doctor's notes to a tabloid newspaper.
Dr. Simon performs brain surgery on a friend suffering from Parkinson's and then has to deal with the man's mother when things go wrong. Dr. Geiger deals with a doctor who is doing research into human cloning and with an elderly patient who is ready to die.
At the same time his daughter Alicia needs heart surgery, Geiger is pressured by the board to make massive cuts to the hospital's budget. Conjoined twins arrive in the emergency room, one suffering a cut on his leg, the other needing an appendectomy.
A steroid using wrestler with a knee injury learns she may have cancer. Aaron and Gina come up with a plan to use hypothermia on a young girl to better her chances of surviving brain surgery. Keith's son Ray asks his dad for help with a sick tarantula.
An old friend of Jack's shows up in the ER with a minor gunshot wound and a major heart defect. The conjoined twins return to the hospital and when Jeremy discovers one of them has developed pancreatic cancer, she tries to convince them to have separation surgery.
Gina and Aaron are given permission to perform experimental brain surgery on a paralyzed patient but Jack has to jump through hoops to be allowed to do a hip replacement on an ex-football player. Jeremy and Francesca discuss their feelings about new CEO Hugh Miller.
After suffering a medical emergency, Hugh experiences care at Chicago Hope firsthand. A woman who went into a coma giving birth reawakens after 15 years and is reunited with her husband and daughter. A man is being denied coverage for life saving heart surgery by his HMO who consider the procedure to be experimental.