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Four old friends, Lorenzo Colombo, Silvio Morandi, Giovanni and Tonino Sbarigia Castagna, they meet again in a rally for former students of the University of Bologna after fifteen years. Spent a riotous night, the four decide without the knowledge of their families to crown their old dream: the crossing of the United States from coast to coast.
John decides to go with friends unbeknownst to his wife (on holiday in Senegal with the children) and to avoid being discovered part with very little money and with the knowledge that they can use credit cards. Silvio, convinced communist, was initially left for the Crimea, but is dumped by his girlfriend and decides to join the gynecologist Tonino who came up with the idea of the trip (originally thought to a solitary journey).
Lorenzo, the richest of all, decide to finance the trip to his friends with his "hundreds of credit cards", but arrived in Miami he realizes that his housekeeper Filipino instead of credit cards has put in 24 hours cards ...