According to Executive Producer Brad Buckner, the baby that Lois and Clark found on their doorstep in the series finale was supposed to be Kryptonian royalty. Had they gone to a season five, the storyline was supposed to be Lois and Clark protecting the baby from potential assassins.
This series was already in development several years earlier, when comics writers had decided to have a wedding for Clark Kent and Lois Lane. The producers of the show wanted to have a similar storyline, and did not want to be several years behind the comics in doing it. When it was agreed that the wedding on television would correspond with the wedding in the comics, the comics' writers had to find a new storyline to hold reader's attention in the meantime and give them the readership they had expected the wedding to attract. This led to the now famous "Death of Superman" story.
Dean Cain was the first actor to audition for the part. Series creator Deborah Joy LeVine initially dismissed him as too young, telling her casting director that they were looking for Superman, not Superboy.
In Lois & Clark: The New Adventures of Superman: Neverending Battle (1993), Lex Luthor attempts to test the abilities of Superman. He questions his associates, and remarks that amongst other things Superman could be "faster than a speeding bullet, more powerful than a locomotive, able to leap tall buildings in a single bound." These are the exact words that began Max Fleischer's "Superman" short cartoons made from 1941 to 1943.
Gerard Christopher auditioned for the role of Superman, and was chosen by the Casting Director. However, when the Casting Director subsequently read Christopher's resumé and discovered that he had previously starred as Superboy in Superboy (1988), he immediately dismissed Christopher. According to Christopher, the man told him, "You've done this already!"
Michael Landes was replaced as Jimmy Olsen after the first season, because the producers felt he looked too much like Clark Kent's little brother, instead of just the photographer for the Daily Planet.
John Shea decided to leave the series after the first season, because he was tired of the strenuous commute from New York City to Los Angeles. He would later return for four guest spots during seasons two through four.
Deborah Joy LeVine and her writing team were dismissed after the first season. New Producer Robert Singer, was brought in, with the task of focusing the show more on action, and the romance between Lois and Clark.
Kevin Sorbo originally tried out for the part of Superman. Sorbo would later on go to say, "Way back in 1993, I actually booked 'Lois & Clark', and 24 hours later, they cancelled me, and put in Dean Cain," implying that he got the part, at least for a day. Sorbo and Cain would go on to star in God's Not Dead (2014), but had no scenes together.
One of the early villains describes Superman as the advance guard prior to an alien invasion. He also wonders whether Superman has any telepathic powers. In the very first story featuring the character bestowed with the name "The Superman", Superman was an evil advance guard with special telepathic powers.
In several episodes, S.T.A.R. Labs in mentioned. In the DC comics, Scientific and Technological Advanced Research Labs (S.T.A.R. Labs) was introduced in Superman #246 (December 1971). It plays a major role in both The Flash (1990) and The Flash (2014).
Noel Edmonds would introduce episodes live on the set of his hit BBC show Noel's House Party (1991) (TV Series) which his show proceeded Lois & Clark: The New Adventures of Superman (1993) (TV series) with a link-in during the closing credits by Edmondson, which his show started right away after the closing credits. Dean Cain made a cameo in one show in character as Clark Kent/Superman, which he is tricked by Edmonds into thinking green jelly is Kryptonite.
The same year as the series' final season, Teri Hatcher starred opposite Pierce Brosnan in the James Bond movie Tomorrow Never Dies (1997). The James Bond film franchise was reboot as Casino Royale (2006) with Daniel Craig as James Bond. Henry Cavill whom was speculated to play James Bond in the James Bond reboot was cast as Clark Kent/Superman in Man of Steel (2013) which is a reboot of Superman (1978) and it's 4 sequels.
Recurring antagonist Jason Trask's arc: believing Superman is evil and that he must be destroyed was later reused in Batman V Superman: Dawn of Justice (2016) which Batman/Bruce Wayne (Ben Affleck) believes Superman (Henry Cavill) is the enemy and threatens humanity and decides to fight him.