Brisco County Jr. is hired by the attorney of a group of robber barons to track down and apprehend the infamous John Bly and his gang, a job that was previously entrusted to his late father Brisco County Sr.
Brisco County Jr. and Lord Bowler track John Bly to Colorado, but discover that Bly is obsessed in locating a mysterious gold metallic orb with special powers - and he will use anyone and kill anyone to find it.
Socrates' sister defends Jack Randolph, a man that Brisco brought in on charges of murder and counterfeiting. But is it a case of mistaken identity as Randolph says, or is it a case of a misguided heart on the part of Socrates' sister?
Brisco comes to Socrates aid after he gets into trouble running up a gambling debt with one of the men who killed Brisco's father. And with a little friendly persuasion, Lord Bowler and Dixie Cousins are more than willing to help out.
Blackbeard LaCutte and his gang of pirates are stealing supplies from everyone in the territory, including medicine that is needed to save a young boys life. Brisco and Lord Bowler set out to retrieve the medicine and put an end to Blackbeard and his marauding ways.
Dixie Cousins has in her possession a cylinder recording of an incriminating conversation between John Bly and a high ranking politician. Brisco must find her to see to it that the recording does not fall into the wrong hands.
Every bounty hunter in the land is tracking Brisco after he is wrongly accused of murder. On the run, Brisco himself is hot on the trail of John Bly and enlists the help of Crystal Hawks, a beautiful bounty hunter who is looking to cash in.
Three mail order brides hire Brisco and Lord Bowler to find the Swill brothers after they stole their dowry's from them. Meanwhile, Socrates Poole prepares for the arrival of a million dollar "royal" bull that is a gift from Spain.
Brisco, Lord Bowler, and Socrates Poole travel to an unpopulated island for a bounty hunters convention, but soon after they arrive they discover that someone is trying to systematically kill all of the attendees.
The daughter of a professor who has extensive knowledge of the orb is behind a series of double crosses to ensure that her father can continue to make a fountain of youth elixir that she needs to maintain her youthful appearance.
Brisco, Lord Bowler, and a town sheriff that strangely enough acts and looks a lot like Elvis Presley help local store owners that are being victimized by a protection for money racket run by a man named Hondo.
Two orphans from Brooklyn are on their way to San Francisco so they can inherit three million dollars, but there are those who want to prevent them from getting there on time-luckily Brisco and Lord Bowler are there to help out.
A naked beauty appears in Brisco's hotel room and explains to him that she is a time traveler from the future, and that her race created the orbs. She pleads to him that the future is in his hands, but he must stop John Bly that night.
Brisco County Jr. tracks down the notorious bank robber Ned Zed, who also happens to be a former member of John Bly's gang. Along the way he runs into Lord Bowler and an old flame and enlists their help in snaring Ned .
Brisco is hired by the U.S government to escort a female prisoner by the name of Emma Steed to Mexico in exchange for a political prisoner. Along the way he discovers that Ms. Steed is actually a spy working undercover for the government.
Brisco and Bowler are entrusted in guarding a stagecoach load of money to Reno for the Governor of Nevada. En route they're robbed by masked men. Brisco recognizes one of them as Dixie Cousins, and they soon learn it was for a good cause.
Brisco, Bowler, and Dixie protect a baby that was left with Dixie by Pete Hutter. They learn that the baby is Emperor and heir to all of China and that the Black Lotus gang and it's leader want the baby so they can rule China through him.
Brisco, Bowler, and Whip track Socrates Poole to a strange little town after he is kidnapped on his birthday. Meanwhile, it appears that Socrates is being held by a man who he helped convict of murder, a man that he saw hang ten years ago.
The calvary arrests Brisco County Jr. and Lord Bowler under the accusation of high treason. They are to be promptly court martialed and executed by firing squad. Can they prove their innocence before it's too late?
With the help of Prof. Albert Wickwire, Brisco County Jr. and Lord Bowler manage to fake their deaths and escape. Now on the run, they must prove that a rogue general is behind everything, before his deadly posse tracks them down.