According to writer Robert Engels, he and director David Lynch originally conceived this film as the first in a series of films exploring the mythology of the Black Lodge. To that effect, the two inserted four characters as "outs" with which to continue the story: Agent Dale Cooper (Kyle MacLachlan), Agent Phillip Jeffries (David Bowie), Major Garland Briggs (Don S. Davis) and Agent Chester Desmond (Chris Isaak). The critical and box-office failure of this film, however, caused Lynch to abandon any plans for sequels.
Richard Beymer (Ben Horne) declined to participate due to a scene where Ben was to force Laura to kiss him in exchange for a bag of cocaine. Beymer felt that there had been no buildup for the character of Horne (who confesses his love for Laura in Twin Peaks (1990)) to extort Laura, and that as a result the scene came off as exploitative. As a result, another scene, in which Leland Palmer (Ray Wise) confronts Ben about Laura's photo being on Ben's desk, resulting in a fight with Ben's wife, was never shot. The scene also would have included Johnny and Jerry Horne.
Originally announced for production shortly after the cancellation of Twin Peaks (1990), the film was shelved when several key members of the cast - notably Lara Flynn Boyle, Sherilyn Fenn and Kyle MacLachlan - declined to participate. MacLachlan, in particular, adamantly refused to appear for fear of typecasting. Director David Lynch managed to persuade the actor to return albeit in an abbreviated role, and created the character of Agent Chester Desmond (Chris Isaak) to compensate for Cooper's absence in the story. This created several continuity errors (the degree of which is still debated among fans) between the film, the series and several canonical tie-in novels.
In most versions of the film certain sequences are sub-titled - at the nightclub where the music drowns out the dialogue and when characters speak backwards - but not in the British version. Apparently, director David Lynch changed his mind so often as to whether they should be included or not, by the time he came to a final decision, the British distributors had already made all their prints (without subtitles) and couldn't afford to make any more.
Contrary to rumors that she refused the chance to reprise her Twin Peaks (1990) role (which is taken over by Moira Kelly) because of the film's nude scenes, Lara Flynn Boyle's absence from Fire Walk With Me was actually due to scheduling conflicts, as she had prior obligations to four other films.
The song "Sycamore Trees" featured in Twin Peaks: Episode #2.22 (1991), but appearing on the movie soundtrack, is claimed by Norwegian pop group A-Ha to be an unauthorized cover of their song "Sycamore Leaves" written in 1989. A-Ha band member Pål Waaktaar sued David Lynch (Lynch wrote the lyrics for Sycamore Trees) for plagiarizing, but eventually lost the case.
Robert Engels claims the script that he and David Lynch wrote is much longer than the version that Lynch actually filmed. He claims there is enough story for a sequel. Indeed, as with many other Lynch films, about five hours of footage was shot. Many of the scenes that ended up on the cutting room floor involved characters who appeared in Twin Peaks (1990) but not in the movie. These scenes include: Sheriff Harry Truman singing to Josie Packard, Johnny Horne's birthday party, Bobby Briggs' parents reading from the Bible, Doc Hayward performing magic tricks and a fight scene between FBI Agent Chester Desmond and Sheriff Cable.
The convenience store sequence refers back to one of the first episodes of Twin Peaks (1990), when Philip Gerard, under the influence of Mike, tells Cooper that the Black Lodge spirits lived above a convenience store when in the human world. According to Michael J. Anderson (Man From Another Place) the scene originally ran for twenty minutes; only about one minute actually appears in the film.
The zigzag pattern on the floor of the Black Lodge is similar to the pattern on the floor of the lobby of Henry's house in Eraserhead (1977), also directed by David Lynch. The Black Lodge version of the pattern is much larger.
All the members of the Blue Rose team, other than Agent Cooper, are played by musicians: Chris Isaak, David Bowie, and Miguel Ferrer. Bowie and Ferrer have both worked with Bing Crosby. Bowie recorded a Christmas album with him, while Ferrer worked as a drummer when Crosby went on tour with his mother Rosemary Clooney. Chrysta Bell, who appears in Twin Peaks: The Return as Agent Tamora Preston, is a composer and performer of avante garde Dreampop music and has collaborated with David Lynch on recordings.
When Laura and James are talking in the woods about Bobby killing someone Laura sees something in the woods that makes her scream. In the 2017 Twin Peaks TV series it is revealed what Laura actually saw.
The character name Gordon Cole was Lynch's first reference to Sunset Blvd. (1950). The television series already had a character named Norma Jennings. This film has a character named Chester Desmond. Norma Desmond was the name of the female lead in Sunset Blvd. In the 2017 series, Cooper is brought out of his catatonic state by hearing the name Gordon Cole from that film.
Both Sheryl Lee and Moira Kelly have worked together prior. TV movie Love,Lies and Murdet TV Show One Tree Hill. Kelly played Chad Michael Murrys mother. Sheryl Lee played Hilarie Burton's biological mother in the show
The trivia items below may give away important plot points.
One pivotal scene deleted from the final film revealed the fate of Annie Blackburn (Heather Graham) after the ending of Twin Peaks: Episode #2.22 (1991). After escaping the Black Lodge, Anne was taken to the hospital where it was discovered that she was wearing the Owl Ring that belonged to Theresa Banks and Laura Palmer. A nurse then took the ring, and started laughing maniacally.
The movie originally ended showing Dale sitting in the Black Lodge, comforting Laura after she entered. It then cut to the last scene of the TV series - Twin Peaks: Episode #2.22 (1991) - with Harry breaking down the door of the bathroom and finding Dale smashing his head into the mirror and laughing. Dale tries to act like nothing happened, but is dragged off to bed. This was to confirm that it was Dale's doppelganger that escaped the Black Lodge.
Another deleted scene which took place after Laura's death extended the dialogue between Cooper and The Man From Another Place. Just after the dwarf says "I am the arm," Cooper notices that the ring disappeared. He then informs Cooper that someone else has taken the ring, and implies that Cooper is trapped in the Lodge forever.
There's a very good reason why parts of the movie may seem nonsensical. According to writer Robert Engels, this film was meant to be only the first entry in the planned trilogy of sequel films that would have wrapped up the unfinished storyline from the Twin Peaks television series. Fire Walk With Me was the prequel, while the next film in line was suppose to be the first proper sequel and resolve the cliffhanger ending of the show as well as focus on the doppelgangers and the Black Lodge. Major Garland Briggs was suppose to go looking for the real Dale Cooper. More doppelgangers would have shown up in town. Agent Phillip Jeffries was suppose to explore the second portal to the Black Lodge that's located somewhere in Argentina and this would have led to the discovery of several more such portals located around the world. The enigmatic woman called Judy whom Jeffries mentions in the film was suppose to be Josie's sister.