Lorenzo's Oil (1992)

A boy develops a disease so rare that nobody is working on a cure, so his father decides to learn all about it and tackle the problem himself.

Director:

George Miller

Writers:

George Miller, Nick Enright

Stars:

Nick Nolte, Susan Sarandon, Peter Ustinov

Nominated for 2 Oscars. Another 6 nominations.

Cast

Cast overview, first billed only:
Nick Nolte	...	Augusto Odone
Susan Sarandon	...	Michaela Odone
Peter Ustinov	...	Professor Nikolais
Kathleen Wilhoite	...	Deirdre Murphy
Gerry Bamman	...	Doctor Judalon
Margo Martindale	...	Wendy Gimble
James Rebhorn	...	Ellard Muscatine
Ann Hearn	...	Loretta Muscatine
Maduka Steady	...	Omouri
Mary Wakio	...	Comorian Teacher
Don Suddaby	...	Himself
Colin Ward	...	Jake Gimble
LaTanya Richardson Jackson	...	Nurse Ruth (as La Tanya Richardson)
Jennifer Dundas	...	Nurse Nancy Jo
William Cameron	...	Pellerman

Storyline

Until about the age of seven, Lorenzo Odone was a normal child. After then, strange things began to happen to him: he would have blackouts, memory lapses, and other strange mental phemonenons. He is eventually diagnosed as suffering from ALD (adrenoleukodystrophy): an extremely rare incurable degenerative brain disorder. Frustrated at the failings of doctors and medicine in this area, the Odones begin to educate themselves in the hope of discovering something which can halt the progress of the disease.

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Plot Keywords:

hope | doctor | reference to jesus christ | what happened to epilogue | ends with real life footage | 

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Taglines:

Some people make their own miracles.

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Genres:

Drama

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Motion Picture Rating (MPAA)

Rated PG-13 for a child's life threatening ordeal

Details

Country:

USA

Language:

English Italian

Release Date:

29 January 1993 (USA)

Also Known As:

Un milagro para Lorenzo

Filming Locations:

Washington Dulles International Airport - 45020 Aviation Drive, Sterling, Virginia, USA

Box Office

Budget:

$30,000,000 (estimated)

Opening Weekend USA:

$79,353, 3 January 1993

Gross USA:

$7,286,388

Cumulative Worldwide Gross:

$7,286,388

Company Credits

Production Co:

Universal Pictures, Kennedy Miller Productions

Technical Specs

Runtime:

129 min

Sound Mix:

Dolby SR

Color:

Color (Technicolor)

Aspect Ratio:

1.85 : 1

Did You Know?

Trivia

Don Suddaby (himself) is the actual British biochemist that has synthesized the pure oil (erucic acid) that was used to treat Lorenzo. He was born in Kingston upon Hull, England, where he has a street named after him, "Suddaby Close", which runs adjacent to "Lorenzo Way".

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Quotes

Augusto Odone: Michaela! They are the same enzyme! There is one enzyme for both chains. It's the same bloody enzyme!

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Crazy Credits

During the credits pictures of children are shown, which were cured by "Lorenzo's Oil".

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Connections

Referenced in Batman vs. Two-Face (2017)

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Soundtracks

Adagio for Strings
Written by Samuel Barber (as Barber)
Performed by Philharmonia Virtuosi
Conducted by Richard Kapp

User Reviews

Painful, Yet Moving True Story....

Definetly one of the most inspiring movies ever made.

As individuals, it would be quite easy to feel helpless while up against a disease such as ALD and a medical establishment that has agendas other than the life of a small child. But Augusto and Michaela Odone refused to just stand idly by and while there son's life slipped away from them. Instead, they made the unprecedented decision to learn as much as they could about their son's devastating illness and then set about to find a cure. Because of their efforts, thousands of boys will now be able to enjoy a life their child will not. Had they not been the exceptionally educated and intelligent people that they were I don't know if they would have been able to accomplish such an unbelievable feat. Who knows? What's important to remember, and what I think is the moral of the story is that great things can be accomplished when people become determined to make a difference.

Though Lorenzo regained his sight, some motor skills, and the ability to swallow, his condition hasn't improved to a large degree over the years, and will not until science is able to regenerate the myelin sheath covering his brain that was all but destroyed by the ALD. At the end of the movie, Augusto was involved with a group of scientists who were about to begin trials that would put the myelin back into some puppies who were born with this defect. I, along with others pray for those suffering from this disorder, as well as for people with other diseases such as Multiple Schlerosis that this therapy could help, that they will be successful.

Sadly, Michaela passed away not too long ago. Being from Virginia the Odone's are considered heros in this state, so her death made the papers here. I cried when I thought of how difficult it must have been for her to have to leave the child she'd spent so many years giving hours upon hours of endless care and attention. I'm sure it never crossed her mind that he would outlive her.

If you've never seen this movie, be sure not to miss it. It's a stellar 10!! But be sure to bring a whole box of tissues, you're going to need it!