An internal affairs officer that Reno was partners with when he was a cop feels her life is being threatened. The culprit is a former dirty police officer that she brought to justice, turned motorcycle gangster kingpin. After he makes several attempts on her life, she contacts Reno to assist. Reno assumes the identity of the gangster after he dies in a tragic accident, in order to more deeply investigate and expose the ongoing organized crime operation.
Hot on the trail of a corrupt banker that embezzled millions of dollars, Reno and Bobby trace the bounty to a remote resort. However, this is no ordinary tourist paradise, as it serves as a front for a clinic that offers new identities to wealthy fugitives via expensive and risky plastic surgery operations. While still trying to collect the bounty, Reno actually contemplates getting the procedure done himself to shake his legal troubles.
A criminally insane man escapes and gets the better of a local police officer. Rather than elude law enforcement, he decides to have some fun first and go on a spree, impersonating an officer. It's up to Reno and Bobby to bring the bounty back into custody before he pulls off a planned heist, or before his anti-psychotic medication runs out and he does any serious damage. They also must contend with the police officer that let the criminal get the jump on him in the first place, who wants them off the case.
A string of recent murders leaves a college campus paralyzed in fear. Bobby decides to handle this case solo, but is too ambitious and ends up getting captured by the stalker himself. He and a female victim get locked in a torture chamber for several days, and are beaten, starved, and subjected to mind games. Reno and Cheyenne must rescue them from the stalker, while also contending with bureaucratic local law enforcement that don't want any interference in the case.
A man goes belly-up financially and is subsequently left by his wife and kids. This causes him to lose his mind, and embark on a killing spree, murdering collectors and repossession agents. Once he gains access to some high-tech weaponry, it can only mean bad news for everybody. Reno goes undercover as a repo agent to investigate the murders and catch the killer.
After catching a bounty, Reno gets involved with a country music singer and falls in love with her. He goes on tour with her acting as her personal bodyguard. The tour gets messy when she gets pressured by her agent to sign a new contract, and it appears her life is in danger when she is unwilling to cooperate. A bizarre turn of events leads Reno to the truth behind the conflict.
Bobby and Cheyenne move in too soon on a bust. The situation is too hot, and Cheyenne gets injured badly by a grenade. She survives the explosion, but spends several months recovering in intensive care. Reno and Bobby blame each other for the attack, and have a falling out. Reno tried to retire to the mountains and live the quiet life, but it is proven once again that he cannot shake Dutch Dixon off his tail no matter where he goes. Reno and Bobby must put their differences aside in order to catch the men who hurt Cheyenne.
A high priced professional hitman sets his sights on Reno, although he is not interested in killing him, rather, he has different plans for him. Diagnosed with a terminal illness, he wants Reno to continue on with his business operations, as well as care for his disabled daughter after he passes on. In order to seal the deal, Reno must terminate Dutch Dixon. In exchange for his services, Reno is promised a new life and a clean record.
A foreign ambassador is running a lucrative drug smuggling operation, hiding behind the cover of diplomatic immunity. His legal representation is a very attractive woman, who Reno falls in love with. The two plan to get married, as well as bring down the drug dealer. In the mean time, Dutch Dixon gets promoted to a US Marshal, giving him more power and resources than ever before. This seriously complicates their wedding plans.
Bobby and Reno take a much needed vacation to Mexico. The two agree not to discuss any business on the trip, but that pact is short-lived. They soon find themselves mixed up in the aftermath of a multi-million dollar casino heist caper, involving kidnapping, counterfeiting, and police corruption.
After winning a poker game, Bobby gets a hot tip on a legendary fugitive. He tracks the man to a small remote village, and finds the whole town has been going to great lengths to keep the man's identity a secret. While Bobby and Reno have been on their own quest to uncover the identity of the fugitive, they must contend with a rival bounty hunter who is after the same thing.
Cheyenne places a "most eligible bachelor" personals ad for Bobby in a magazine, and they get flooded with responses. However, Bobby finds romance in the strangest of all places, as he falls in love with the victim of a recent automobile accident he was involved in. While all of this is happening, Reno is on the trail of a fugitive, but a strange series of coincidences leads him to believe there may be an ulterior motive to her seduction of Bobby.
A woman escapes from a correctional facility and goes on the run. Reno and Bobby take on the case, and enlist the help of a local Sheriff. After doing some investigating of their own, they discover the Sheriff hasn't been playing it straight with them, as he has a history of extra-marital affairs with the woman. The more deeply Bobby and Reno get involved in the case, the thicker the lying, deception, scandal, and betrayal gets. They must decide if the case is even worth pursuing or not.
Reno poses as a ranch hand once again, and uncovers a plot where con artists are selling illegitimate horses as supposed top thoroughbreds. What makes things worse is that once the sale is made and the money is collected, the animals are killed. This is done to destroy any evidence of wrongdoing before the buyers suspect anything. Reno has to determine who is in on the scam and who is just an innocent bystander before exposing the operation.
Reno goes to see Lisa, the daughter of the hit man who was sent to kill him but ended up asking Reno to look after her. While there, someone breaks into the house. Reno thinks it might have something to do with her father's profession which she knows nothing about.
A well publicized death at a regatta gets Reno's attention when he sees his dead fiancée's sister on television. The death is ruled accidental but Reno investigates first hand, both to protect his friend, and because he suspects foul play. He finds that the death was no accident, and that the boat races are really a front to smuggle illegal weapons out of the country to supply a revolution.
A woman from Bobby's past gets victimized by an upscale male escort service that sets up robberies on its wealthy clients. They are blackmailing her with revealing photographs of her recent rendez-vous, preventing her from going to the cops. Bobby and Reno decide to help out, against her wishes. Reno poses as an escort himself to get to the heart of the operation.
A mafia prince is murdered in broad daylight. The assassin is so well connected that he is virtually untouchable. Reno and Cheyenne pose as a couple on honeymoon, since they feel that Cheyenne is the only way to lower his guard and get close to him. They must catch him before he leaves the country. While trying to catch the killer, Reno and Cheyenne get dangerously close, and begin falling in love.
Dutch Dixon's son Donnie gets out of prison. He decides that he will sell his father up the river for the right price. Although he contacts Sixkiller first, he cuts a more profitable deal with a former police officer that Dutch screwed over to get ahead. Even after all of this, Reno still insists on being involved, feeling that he can't pass up the opportunity to bring down Dixon. In a strange twist of fate he finds himself saving Dutch Dixon rather than persecuting him.