Duncan Macleod, an IMMORTAL who lives quietly with his girlfriend, Tessa, will have to deal with a young man who tries to steal his antiquities store and an evil rival immortal who wants to take his head, forcing him to return to THE GAME.
Duncan bails Richie out of jail after he was caught stealing files from an adoption agency in an effort to find out who his parents are. From what Richie read in the files before he was caught, he and Duncan are able to find a man who claims to be his father. Duncan senses that something isn't right, so he hits the streets to find out who this man really is.
A friend of Richie's dies suddenly after being captured during a diamond heist. The police believe it to be a drug overdose, but Richie insists his friend would never have done drugs. Duncan believes it to be the work of a potion developed by Kiem Sun, an immortal he once knew.
On his way home from the grocery store, Duncan is the victim of a hit and run. He is rushed to the hospital in critical condition, but due to his remarkable recovery time he is able to check himself out shortly after he arrives. This is noticed by a doctor who drugs and kidnaps Duncan so that he can experiment on him. Meanwhile, reporter Randi MacFarland is hot on the trail of Duncan's disappearance.
Richie saves an old friend from Russian mobsters after a drug deal goes bad. Unbeknown to him, she takes the drugs and the money with her. It is up to Duncan to protect her and her daughter from the mobsters, who are now looking for her.
While browsing Duncan's antique store, a mysterious woman named Rebecca Lord inquires about a sword that he once took from a rival immortal named Walter Reinhardt. Duncan agrees to let her test the sword, and he is shocked to find that she uses the same style as Reinhardt. Having never taken Reinhardt's head, Duncan fears that the two may be working together to defeat him.
A friend of Tessa's is assaulted and nearly killed by a serial killer who scalps his victims. Duncan believes him to be a copycat killer who is basing his crimes on those of an immortal whom Duncan confronted years ago.
An immortal named Grayson is targeting the friends and disciples of his old friend Darius, an immortal who was once a great warrior but is now a Catholic priest. Darius sends Duncan a message warning him of Grayson's treachery, and Duncan must protect Grayson's next target.
An immortal thief named Xavier St. Cloud visits Darius and confesses his crimes to him after a robbery during which he murdered six people. According to the laws of the Catholic Church, Darius cannot reveal to the police what he learned during St. Cloud's confession. Duncan, who suspects that St. Cloud was responsible for the crime, then takes it upon himself to find him.
During a rehearsal, the manager of a band is thrown from a balcony and killed while having an argument with the band's lead singer. Duncan, who is there with Tessa and Richie as guests of the backup singer, believes the manager was killed by a mentally handicapped immortal he once befriended.
Grace, an Immortal who has focused on healing rather than fighting, is framed for the murder of her mortal husband by an obsessed ex-lover, the Immortal Carlo Seandaro. Duncan must step in to protect her from her own weakness.
Amanda, an immortal thief and former lover of Duncan, is confronted by the immortal Zachary Blaine, her former partner in crime. She convinces him not to kill her in return for providing him with the chance to take Duncan's head.
Gabriel Piton, an immortal fashion designer, kills one of his models after she finds a stash of stolen artifacts in his apartment. Now the girl's roommate, who is an acquaintance of Richie's, is in danger of the same fate, and Duncan, who is an old friend of Piton's, must step in to prevent his friend from killing another innocent person.
Mark Rothwood, the son of diplomat Allan Rothwood, rapes the step-daughter of the immortal Colonel Bellian. Duncan, Tessa, and Richie go to the Rothwoods' house to visit Allan, who is an old friend of Tessa's, and Bellian shows up for revenge. Believing that Rothwood deserves a fair trial, Duncan must guard the house against the siege of Bellian and his team of mercenaries.
Duncan receives a visit from an old friend, the immortal Hugh Fitzcairn. Fitzcairn informs him that several immortals have gone missing recently, and that he thinks something isn't right. When Darius is killed in his church they know that it isn't the work of another immortal, so they vow to avenge Darius by finding who is responsible.