Burt Reynolds turned down the lead role, because his then wife, Loni Anderson, told him that the whole of Hollywood would laugh at her, as Reynolds and Sally Field once had a very publicized love affair.
David Barnes (Robert Downey, Jr.) was originally written as a fifty year old man. But Director Michael Hoffman, who had worked with Downey before on an unfinished film called "Back East", had the part re-written to fit Downey's age.
Michael Hoffman says in the Director's commentary of Game 6 (2005), "I remember when we made Soapdish, I wanted to shoot on 47th Street (in New York City), and they wouldn't even let us shoot on 47th Street, you know, off Times Square. They said they couldn't guarantee your safety."
Rose Schwartz (Whoopi Goldberg) reacts to Montana Moorehead (Cathy Moriarty) saying, "I too have an oath, a nurse's oath" with scorn, as though it's completely ridiculous, but nurses do frequently take an oath called the Nightingale Pledge. It's modeled after the Hippocratic Oath sometimes taken by doctors, although neither are required.
According to the Turner Classic Movies website, "During (the) fall of 1991, United International Pictures (UIP) and New World International launched a joint marketing campaign in Europe to cross-promote Soapdish (1991) with Santa Barbara (1984), "a prime-time soap opera". Stephen Nichols would appear as Dr. Skyler Gates in seven episodes of Santa Barbara (1984) in the year after this movie was released.
The number of times that Celeste Talbert (Sally Field) had been nominated for a Daytime Television Award was twelve. In real-life, (as of June 2015), Field has been nominated for three Golden Globe Awards for television productions, and nine Primetime Emmy Awards. These total twelve television nominations, the same number of times as her character has been nominated for the fictional Daytime Television Awards in this movie. In real-life, Field has won two Academy Awards from three Oscar nominations, and won three Primetime Emmy Awards.
There is a moment when Celeste and Rose are walking along the street, and they pass by a place where there is a movie poster for the Gene Wilder film Funny About Love (1990). That film was also released by Paramount, and probably was there, because at the time they shot the scene, that film was soon to be released in theaters, so it happened to be there.
The name of the play that Jeffrey Anderson (Kevin Kline) was starring in at a cheapo steak 'n' play house dinner theatre in Opa-Locka, Miami-Dade County, Florida, was as Willy Loman in Arthur Miller's "Death of a Salesman" (1949).
Celeste is presented with the fictionalized version of a Daytime Emmy award. Leeza Gibbons, who plays herself as a reporter for Entertainment Tonight (1981), interviews her before the ceremony and later watches as Celeste's personal soap opera is revealed. In real life, Leeza is the winner of an Daytime Emmy for Outstanding Host in a Lifestyle or Travel program for the PBS show, My Generation (2008).