A vengeful voodoo priestess ensnares Arcane in a voodoo curse as revenge for his enslavement of Jim Kipp, who had once saved a cousin of hers from drowning. Alec helps Graham and a kindly voodoo priest save Arcane from certain death.
Killer mist from the swamp attacks Houma, putting residents in grave danger. Arcane and Alec team up to to find an antidote, while Abigail and Will hunt for a boy who may be lost in the mist. Can they stop the mist before someone gets hurt?
Sheriff Andrews allows Dr. Arcane to hunt an employee for sport. To teach Andrews a lesson, Alec traps him a fantasy of the old west populated by familiar faces, forcing him to duel the evil Renegade Jake in a fight to the death.
Temporally displaced Confederate Civil War soldiers appear in the swamp, one of whom is a previous residence of Will's house. Will helps the man to discover the mystery behind his wartime disappearance and make peace with his past so he can pass on.
Arcane resurrects his wife Tatania only to learn the woman he's kept frozen all these years is Kitty Lane, an exotic dancer and impostor placed in Arcane's lab by General Sunderland. Sunderland has been holding the real Tatania captive.
When Arcane hires mercenaries to kill Swamp Thing, the injured creature uses Anne Fisk's equipment to try to heal himself, temporarily becoming human again. Tressa discovers his secret, and tries to help him.
A glimpse into a future devastated by man-made environmental disaster ensures that Senator Parker will take action to prevent it happening - to the best of his ability, at least. But that may not be enough.
When Dr. Arcane "dies" during a mutation experiment gone wrong, Graham accuses Stella of attempting to replace him in the lab by seducing Arcane. During their fight Graham falls for Stella, conceding that Arcane must have seduced her "in mind, if not body." Their tender moment is ruined, however, when Graham is alerted to a break-in at the lab: it's Dr. Arcane, reduced to his inner beast by the failed experiment. Can Graham stop him before tragedy strikes?
Two spoilt rich girls inveigle Will, against his will, into taking them into the swamp so they can perform a ritual to give them three wishes. In the course of teaching them a lesson in humility, Will makes a discovery about himself.
Arrested for a murder he did not commit, Will's situation looks desperate when his attorney turns out to be a crooked prosecutor with ambitions to rise to the senate. Can Alec help prove his friend's innocence?