The untitled project, which Kenner will produce, will explore how events leading up to that day can affect the reality she lives in. Kaufman is executive producing, writing and directing.
Kaufman and Keener have worked together in the past on films including "Synecdoche, New York," "Being John Malkovich" and the upcoming "Frank Or Francis."
Over the course of her career, Keener has only made a handful of TV appearances. She appeared in the short-lived TV series "Ohara," did an episode of "Seinfeld" and a few TV movies including "If These Walls Could Talk."
If the Keener/Kaufman project makes it to series, it would join HBO's growing line-up of female-fronted comedies. The network currently has "Veep" starring Julia Louis-Dreyfus, "Girls" from Lena Dunham