The Pound Puppies and Holly meet Buster, a puppy who is "a walking natural disaster". They are later invited to the Bellveshires' mansion in hopes of saving the pound from Katrina Stoneheart's latest dastardly plot.
The Pound Puppies rescue a pregnant dog from a severe snowstorm. However, when the power gets knocked out, it's up to Cooler, Howler, and Whopper to find a nearby veterinarian while the girls tend to the soon-to-be mother.
A trio of dogs, known as the Three Wise Guys, are looking for a legendary canine called the Star Puppy and Nose Marie was selected. Meanwhile, Captain Slaughter is also looking the Star Puppy and aims to make a fur coat out of Nose Marie!
Holly's Puppy Pound finally, and unfortunately, closes down no thanks to Katrina Stoneheart, Brattina, and Catgut. With no hope in sight, only a Christmas Miracle will once again open Holly's Puppy Pound.