With the First Lady coming to Boston, St Eligius is chosen by the Secret Service to care for her, if needed. As the staff prepare and enter alert mode, Ehrlich reports a case of potential child abuse and Shirley Daniels returns.
Chandler must try convince a clown with MS to quit the circus; Axelrod meets with a lawyer about Mrs. Hufnagel's estate; Morrison hits a low point in both his professional and personal life; Caldwell's facial surgery patient expresses her feelings for him.
Luther is rushed into surgery after losing his hearing in a boiler room explosion; Auschlander gets some very sad news while reading the paper; Axelrod puts Mrs. Hufnagel to rest; Craig gets some surprising news about his son.
Westphal, Craig and Auschlander go to the bar "where everybody knows your name," manned by a skeleton staff (Carla plus patrons Norm and Cliff). These sequences are not played for laughs (although Auschlander takes a potshot at Norm for bungling his taxes). During the meeting at Cheers, Westphal announces he is quitting medicine. Craig later meets an old mentor who is suffering from advanced dementia and doesn't recognize him. An Easter theme runs through this show as a man claiming to be the Messiah shows up for a Celtics game, is crucified by a bunch of thugs, ...
Auschlander and Craig have trouble dealing with the resignation of Westphall; a mentally ill amnesia patient gets mistaken for the chairman of the Residency Review Committee; Chandler and Morrison have a falling out over Vietnam.
The Craigs prepare for Stephen's funeral; Caldwell's sexual indiscretions lead to a practical joke being played on him; Westphall tries to sell the hospital board on increasing funding for malnutrition; Luther agrees to help Axelrod lose weight.
The Craigs meet Yvonne's parents and their relationship gets off to an icy start; Westphall's efforts to start a hunger unit in the hospital takes a toll on his health; Caldwell's sexual escapades take a scary turn; a cancer patient's impotence following an operation causes Fiscus to reflect on his own life.
Westphall is visited by his daughter at the hospital; the Residency Review Committee puts pressure on Caldwell and Turner to perform more surgeries; Axelrod's inability to lose weight costs him a relationship; two mentally challenged patients are caught having sexual intercourse; an astronaut is treated for an unknown condition which causes paralysis in his legs.
Craig travels to Clinton, NY in hopes of bringing back his granddaughter; Ehrlich clashes with Caldwell over an unnecessary plastic surgery; Morrison goes against the US Military by refusing to discharge an astronaut; John Doe takes the identity of Mary Richards from "The Mary Tyler Moore Show".
Craig gets a surprise visitor with good news; Ehrlich is demoted to gynecology; Westphall treats a patient who is suffering from malnutrition; Morrison takes the Remedial Exam for the third time; the tension between Rosenthal and Papandrao hits a boiling point; Chandler's romance with Turner faces a major hurdle.
Fiscus is reunited with a homeless man that once helped him move; Ehrlich helps deliver a baby; Westphall's housekeeper is admitted to the hospital with a back injury; Caldwell steps over the line with Papandrao.
There is a citywide blackout in Boston and St. Eligius is hit hard. The so-called "back up" generator does not start automatically and this endangers surgery. Therefore, the Drs. Auschlander and Craig decide to turn off power for all "unnecessary" parts of the hospital, including the elevators. However, Dr. Westphall is stuck in the elevator with a character; Dr. Fiscus proposes to his lady love and she accepts.
Santa Claus comes to the hospital and collapses while meeting the children; the Craig hosts a Christmas party; Ehrlich is upset when no one buys him any gifts; Westphall has Lizzy and her boyfriend over for the holidays.