The picture has been well-known for its famous sequence where a spider drops into the mouth of a woman. The girl in question was portrayed by a then unknown Sharon Stone who also was the face on many movie posters for the film. Stone would later go on to big fame around a decade later with her breakthrough film role in Basic Instinct (1992). Director Wes Craven tried to persuade Stone to film the spider scene by holding the creature himself. Still unconvinced, Stone requested that its teeth be removed. Despite crew knowledge that this would make it incredibly difficult for the spider to feed, the operation was performed and Stone agreed to continue.
The snake sequence in the bathtub was revisited by director Wes Craven after this film with A Nightmare on Elm Street (1984) where the reptile instead was replaced with the finger-knives hand of Fred Krueger.
Wes Craven compared his work with actor Ernest Borgnine to John Carpenter's work with Donald Pleasance in the original "Halloween". He states that Borgnine was the first "big name actor" he had worked with and was at first intimadated by the actor.
The name of the fictitious rural religious sect living in a farming community in Pennsylvania were the "Hittites". The religious group were allegedly based on the Amish Community who would find popular cinema fame about four years later with their central inclusion in the major motion picture Witness (1985). It is stated at one point in Deadly Blessing (1981) that the Hittites "make the Amish look like swingers".
The name the religious cult the Hittites had for an evil demon figure or demonic presence was "Incubus". A horror movie actually called The Incubus (1982) was first released the following year after Deadly Blessing (1981) debuted in cinemas.
Ernest Borgnine had to be taken to the hospital to be treated for a head injury following a mishap involving a horse and buggy. Moreover, Borgnine returned to the set to continue acting in the film three days later.
According to website 'DVD Verdict', director Wes Craven "...was born into a strict Baptist household and attended conservative Christian Wheaton College" with this movie "clearly rooted in Craven's own religious upbringing".